2-[2-Chloro-4-(hydroxymethyl)-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide CAS 693816-01-2
| CAS No. | 693816-01-2 |
| Molecular Formula | C16H15ClFNO4 |
| Molecular Weight | 339.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-[2-Chloro-4-(hydroxymethyl)-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-[2-Chloro-4-(hydroxymethyl)-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide (CAS 693816-01-2), molecular formula C16H15ClFNO4 and molecular weight 339.75 g/mol, is a CATO reference standard with documented purity and traceability.
2-[2-Chloro-4-(hydroxymethyl)-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide (C16H15ClFNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-[2-Chloro-4-(hydroxymethyl)-6-methoxyphenoxy]-N-(4-fluorophenyl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15ClFNO4 |
| Molecular Weight | 339.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
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Recommended Standards
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- 2-(3-(Chlorosulfonyl)benzamido)benzoic acid (CAS 183871-39-8)
- Chlorthalidone impurity 19 (CAS CATO-C4X-158519)
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- Tert-butyl 3-((5-fluoropyrimidin-2-yl)oxy)piperidine-1-carboxylate (CAS 1261230-08-3)
- 4-Chloro-5H-pyrimido[5,4-b]indole hydrochloride (CAS 107400-97-5)
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- 3-(Furan-2-yl)-1-(3-((2-methylpyrimidin-4-yl)oxy)pyrrolidin-1-yl)prop-2-en-1-one (CAS 2034894-13-6)
- (4E)-4-[(2-Aminopyridin-3-yl)methylene]-3-(chloromethyl)isoxazol-5(4H)-one 1142199-89-0 (CAS 1142199-89-0)
- 2,6,10-Dodecatrien-1-ol, 2,7,11-trimethyl-, (E,E)- (CAS 16910-29-5)
- 1217052-36-2 N-(Phenoxy-d5-acetoxy)succinimide (CAS 1217052-36-2)
- Methyl 5-chlorothiazole-4-carboxylate (CAS 1784463-68-8)
- Semaglutide impurity 22(OtBu-Ste-γGlu(OtBu)-AEEA-AEEA-OH) (CAS 1118767-16-0)
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