3-chloro-6-ethyl-5-Methylpyrazine-2-carbonitrile CAS 440124-23-2
| CAS No. | 440124-23-2 |
| Molecular Formula | C8H8ClN3 |
| Molecular Weight | 181.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-chloro-6-ethyl-5-Methylpyrazine-2-carbonitrile.
CATO supplies 3-chloro-6-ethyl-5-Methylpyrazine-2-carbonitrile (CAS 440124-23-2), a certified reference material (molecular formula C8H8ClN3, MW 181.62 g/mol) for analytical method development and quality control.
The molecular framework of 3-chloro-6-ethyl-5-Methylpyrazine-2-carbonitrile (C8H8ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-chloro-6-ethyl-5-Methylpyrazine-2-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClN3 |
| Molecular Weight | 181.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- 5-Chloro-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 1000340-14-6)
- 4-Chloro-7-methoxy-1H-indole (CAS 1000341-80-9)
- 4-Chloro-5-ethyl-7h-pyrrolo[2,3-d]pyrimidine (CAS 1004992-44-2)
- 4-Chloro-1-ethyl-1H-imidazo[4,5-c]pyridine (CAS 1025509-11-8)
- 6-Chloro-2-ethylbenzoxazole (CAS 1027019-12-0)
- 6-Chloro-1-methyl-1H-indazol-3-amine (CAS 1031927-22-6)
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Recommended Standards
- 3-Chloro-5-phenyl-4,5-dihydroisoxazole (CAS 62056-52-4)
- 3-Chloro-7,8-dihydroquinolin-6(5H)-one (CAS 944895-64-1)
- 3-Chloro-5-(dimethylamino)isonicotinonitrile (CAS 211571-68-5)
- 3-Chloro-β-hydroxybenzenepropanenitrile (CAS 84466-42-2)
- 4-(Pyrimidin-5-yl)but-3-yn-1-ol (CAS 88940-56-1)
- Praeruptorin B (CAS 73069-28-0)
- 5-(4-Methoxyphenyl)-3-(methylthio)-1,2,4-triazine (CAS 69466-83-7)
- 1-Ethynyl-4-(octyloxy)benzene (CAS 137338-08-0)
- 1,3-Dimethyl-2-(prop-2-ynyloxy)benzene (CAS 21078-03-5)
- Tert-butyl (r)-3-(pyrazin-2-ylamino)pyrrolidine-1-carboxylate (CAS 1186299-89-7)
- 3-Amino-1,2-dihydroisoquinolin-1-one (CAS 5597-05-7)
- (S)-2-Amino-N-(4-chlorobenzyl)-N-ethyl-3-methylbutanamide (CAS 1354015-00-1)
- 1,1,1-Trifluoro-3-(piperidin-1-yl)propan-2-yl 3-chlorobenzoate (CAS 477848-34-3)
- Semaglutide impurity 50 (CAS 2773558-66-8)
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