2-(1H-Indol-1-yl)acetonitrile CAS 4414-73-7

Description

The occurrence of 2-(1H-Indol-1-yl)acetonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(1H-Indol-1-yl)acetonitrile (CAS 4414-73-7), molecular formula C10H8N2 and molecular weight 156.18 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(1H-Indol-1-yl)acetonitrile (C10H8N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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