2,2,2-Trifluoro-1-(7-methyl-3-indolyl)ethanone CAS 443-47-0

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

2,2,2-Trifluoro-1-(7-methyl-3-indolyl)ethanone (CAS 443-47-0), molecular formula C11H8F3NO and molecular weight 227.18 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2,2,2-Trifluoro-1-(7-methyl-3-indolyl)ethanone (C11H8F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

As a certified reference material (CRM), 2,2,2-Trifluoro-1-(7-methyl-3-indolyl)ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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