1-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylpiperidine-4-carbohydrazide CAS 444151-84-2
| CAS No. | 444151-84-2 |
| Molecular Formula | C23H19Cl2F3N4O3 |
| Molecular Weight | 527.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylpiperidine-4-carbohydrazide (CAS 444151-84-2), molecular formula C23H19Cl2F3N4O3 and molecular weight 527.32 g/mol, is a CATO reference standard with documented purity and traceability.
1-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylpiperidine-4-carbohydrazide (C23H19Cl2F3N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylpiperidine-4-carbohydrazide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H19Cl2F3N4O3 |
| Molecular Weight | 527.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- [3S-[3alpha(S*),5alpha]]-3-[[5-(2,4-Difluorophenyl)tetrahydro-5-(iodomethyl)-3-furanyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone (CAS 165115-89-9)
- N-(2,4-dichloro-5-isopropoxyphenyl)-2-((2-oxo-2-((3-(trifluoromethyl)phenyl)amino)ethyl)sulfonyl)acetamide (CAS 341964-78-1)
- 2-{[(3,4-dichlorophenyl)carbamoyl]amino}-3-phenylpropyl N-(3,4-dichlorophenyl)carbamate (CAS 338963-06-7)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(4-iodophenyl)butanoic acid (CAS 2349626-82-8)
- [1-(prop-2-yn-1-yl)pyrrolidin-2-yl]methanol (CAS 1250167-12-4)
- 1-(3-Nitrobenzyl)azepane (CAS 414880-13-0)
- (1-(2-Chlorobenzyl)piperidin-4-yl)methanamine dihydrochloride (CAS 1286274-78-9)
- 3-Nitroadamantane-1-carboxylic acid (CAS 42711-76-2)
- 4-(3-Fluoroazetidin-1-yl)piperidine dihydrochloride (CAS 1403767-21-4)
- Atogepant Impurity 58 (CAS CATO-C4X-328558)
- 2-(3,4-Diethoxyphenyl)-2-oxoacetaldehyde (CAS 952-17-0)
- 3-(Phenylamino)butanoic acid (CAS 63492-84-2)
- 8-chloro-4-methylquinoline-3-carboxylic acid (CAS 1510949-38-8)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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