tert-Butyl 4-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)piperazine-1-carboxylate CAS 444892-59-5
| CAS No. | 444892-59-5 |
| Molecular Formula | C18H26F3N3O2 |
| Molecular Weight | 373.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 4-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)piperazine-1-carboxylate (CAS 444892-59-5), molecular formula C18H26F3N3O2 and molecular weight 373.41 g/mol, is a CATO reference standard with documented purity and traceability.
tert-Butyl 4-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)piperazine-1-carboxylate (C18H26F3N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), tert-Butyl 4-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)piperazine-1-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H26F3N3O2 |
| Molecular Weight | 373.41 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- tert-Butyl (1-(2-amino-1-(4-(trifluoromethyl)phenyl)ethyl)pyrrolidin-3-yl)carbamate (CAS 886365-38-4)
- Cinacalcet N-Oxide (CAS 1229224-94-5)
- 6,7-Bis(4-methoxyphenyl)pyrido[2,3-d]pyrimidine-2,4-diamine (CAS 685107-51-1)
- Cinacalcet Impurity 81 (CAS CATO-C4X-105981)
- Methyl 2-(tert-butoxycarbonylamino)but-2-enoate (CAS 55477-81-1)
- 1-(2-(((Benzyloxy)carbonyl)amino)ethyl)-1H-imidazole-4-carboxylic acid (CAS 1690701-62-2)
- 3-Bromo-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one (CAS 1174429-23-2)
- Isavuconazole HCl (CAS 1121545-23-0)
- N-methyl-1-(5-methyl-6-phenoxypyridin-3-yl)methanamine (CAS 1355179-98-4)
- 2H-Benzo[e][1,2]thiazin-4(3H)-one 1,1-dioxide (CAS 5510-09-8)
- 1-(2,3-Dihydro-1H-inden-5-yl)ethan-1-ol (CAS 4228-12-0)
- 2-(Difluoromethyl)-5-nitrophenol (CAS 1261442-16-3)
- 5-Hydroxypyrazine-2-carbonyl chloride (CAS 1261490-22-5)
- Semaglutide Impurity 143 (CAS CATO-C4X-2226143)
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