4-Chloro-1,3-thiazole-5-carboxylic acid CAS 444909-59-5
| CAS No. | 444909-59-5 |
| Molecular Formula | C4H2ClNO2S |
| Molecular Weight | 163.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-Chloro-1,3-thiazole-5-carboxylic acid (CAS 444909-59-5), a certified reference material (molecular formula C4H2ClNO2S, MW 163.58 g/mol) for analytical method development and quality control.
4-Chloro-1,3-thiazole-5-carboxylic acid (C4H2ClNO2S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClNO2S |
| Molecular Weight | 163.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-nitrothiophene (CAS 13195-49-8)
- 4-Chloro-1-(2-fluoro-ethyl)-1h-pyrazol-3-ylamine (CAS 1427023-63-9)
- 2-Chloro-3-nitrothiophene (CAS 5330-98-3)
- 3-chloro-2-nitrothiophene (CAS 33786-78-6)
- 3-Chloro-4-isothiazolecarboxylic Acid (CAS 933690-30-3)
- 4-Chloro-2-oxo-2,3-dihydro-1,3-thiazole-5-carbaldehyde (CAS 55359-96-1)
- 4-Chloro-5-Isothiazolecarboxylic Acid (CAS 88982-87-0)
- 5-Chloro-1,2,3-thiadiazole-4-carboxamide (CAS 64837-51-0)
Recommended Standards
- 2-Chlorothiazole-4-carboxylic Acid (CAS 5198-87-8)
- 2-Chlorothiazole-5-carboxylic acid (CAS 101012-12-8)
- 5-Chlorothiazole-4-carboxylic acid (CAS 1505987-37-0)
- 5-Chloro-1,3,4-thiadiazole-2-carboxamide (CAS 64837-52-1)
- N-methyl-2-(pyrrolidin-2-yl)pyrimidin-4-amine (CAS 1263378-74-0)
- 4-(Bromomethyl)furan-2(5H)-one (CAS 61934-55-2)
- 5-Bromo-2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1073353-75-9)
- Polyinosinic acid (CAS 30918-54-8)
- 3,6-Di(pyridin-4-yl)-9H-carbazole (CAS 1446275-54-2)
- Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate (CAS 151831-21-9)
- N-allyl-3-bromo-5-fluorobenzamide (CAS 1181497-55-1)
- Benzyl 2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 2450291-49-1)
- 2,2,3,3,4,4,4-Heptafluoro-N-[2-(1H-indol-3-yl)ethyl]butanamide (CAS 331260-81-2)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
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