3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide CAS 445268-85-9
| CAS No. | 445268-85-9 |
| Molecular Formula | C20H19Cl2N3OS |
| Molecular Weight | 420.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide.
3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 445268-85-9) is a high-purity analytical reference standard with the molecular formula C20H19Cl2N3OS and a molecular weight of 420.36 g/mol.
The molecular framework of 3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (C20H19Cl2N3OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19Cl2N3OS |
| Molecular Weight | 420.36 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-N-(2,4-dichlorophenyl)-6-ethyl-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide (CAS 627057-31-2)
- 3-Amino-N-(3,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 625370-26-5)
- 6-Amino-N-(2,6-dichlorophenyl)-4-thia-2-azatricyclo[7.6.0.0^{3,7}]pentadeca-1(9),2,5,7-tetraene-5-carboxamide (CAS 496804-79-6)
- 6-Amino-5-(3-methoxyphenyl)-7-(1-methyl-1H-benzo[d]imidazol-2-yl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile (CAS 307343-10-8)
- 6-Amino-4-(4-methoxyphenyl)-1,3-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (CAS 188199-07-7)
- 2-Amino-4-(3-iodophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (CAS 337496-56-7)
- 2-Amino-7,7-dimethyl-1-(3-nitrophenyl)-5-oxo-4-(thiophen-2-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile (CAS 311323-43-0)
- 3-Amino-N-(3,5-dimethoxybenzyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 445267-42-5)
Recommended Standards
- 1-(2-((2,6-Dichlorobenzyl)thio)ethyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid (CAS 306936-26-5)
- 5'-Bromo-1'-tosylspiro[cyclohexane-1,3'-indoline] (CAS 2306271-15-6)
- Tosufloxacin impurity 6 (CAS CATO-C4X-19766)
- tert-butyl N-(6-bromoimidazo[1,2-a]pyridin-8-yl)-N-tert-butoxycarbonyl-carbamate (CAS 2698371-90-1)
- N-Methyl-1-(1-phenyl-1H-pyrazol-4-yl)methanamine hydrochloride (CAS 1255718-31-0)
- 4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156 (CAS 4582-21-2)
- TBTC (CAS 213192-26-8)
- (E)-1,3,5-trimethyl-1H-pyrazole-4-carbaldehyde oxime (CAS 1415313-77-7)
- 4,4,5,5-Tetramethyl-2-(4-methyl-[1,1'-biphenyl]-3-yl)-1,3,2-dioxaborolane (CAS 2253981-35-8)
- Ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate (CAS 6339-66-8)
- 1-(Triphenylmethyl)-1H-imidazole-4-methanamine (CAS 340179-89-7)
- (9H-Fluoren-9-yl)methyl (1,4-oxazepan-6-yl)carbamate (CAS 2830897-49-7)
- 2-Cyclohexyl-1-methylquinazolin-4(1H)-one (CAS 60888-87-1)
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
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