3-Amino-6-ethyl-N-(4-fluorobenzyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide CAS 445268-92-8
| CAS No. | 445268-92-8 |
| Molecular Formula | C21H22FN3OS |
| Molecular Weight | 383.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Amino-6-ethyl-N-(4-fluorobenzyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide.
3-Amino-6-ethyl-N-(4-fluorobenzyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 445268-92-8), molecular formula C21H22FN3OS and molecular weight 383.48 g/mol, is a CATO reference standard with documented purity and traceability.
3-Amino-6-ethyl-N-(4-fluorobenzyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (C21H22FN3OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H22FN3OS |
| Molecular Weight | 383.48 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-6-ethyl-N-(3-fluoro-4-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 625370-20-9)
- 3-Amino-6-ethyl-N-(5-fluoro-2-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 625370-68-5)
- 2-((4-Amino-5-(3-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,6-dimethylphenyl)acetamide (CAS 763114-89-2)
- (2-Amino-1-(cyclohexylsulfonyl)-1H-benzo[d]imidazol-6-yl)(phenyl)methanone (CAS 63197-96-6)
- Propyl 3-(3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamido)benzoate (CAS 691866-89-4)
- 3-Amino-4,6-dimethyl-N-(4-(pentyloxy)phenyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 853743-67-6)
- 4-Amino-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)-3-nitrobenzamide (CAS 1206970-56-0)
- 2-Amino-7-methyl-5-oxo-6-phenethyl-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile (CAS 265315-65-9)
Recommended Standards
- 3-[1-Ethyl-2,2-bis(4-methoxyphenyl)vinyl]-1H-indole (CAS 354146-25-1)
- 4'-Cyano-[1,1'-biphenyl]-4-yl 4-hexylbenzoate (CAS 59443-81-1)
- 3,4-Dimethoxy-N-(3-(4-phenylpiperazin-1-yl)propyl)benzamide (CAS 95138-71-9)
- 4-Methyl-N-[(1S)-1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide (CAS 88129-44-6)
- 3-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)propanehydrazide (CAS 199915-80-5)
- Anti-2-benzyl-2-azabicyclo[2.2.1]heptane-7-carboxylic acid ethyl ester rac (CAS 745836-32-2)
- Phenyl (3-chlorophenyl)carbamate (CAS 50699-50-8)
- Europium(III) sodium 2,2',2'',2'''-(((4'-(4'-amino-[1,1'-biphenyl]-4-yl)-[2,2':6',2''-terpyridine]-6,6''-diyl)bis(methylene))bis(azanetriyl))tetraacetate (CAS 601494-52-4)
- 2-Bromophenyl 2,2,2-trifluoroacetate (CAS 36613-46-4)
- Indacaterol Impurity 23(and enantiomer) (CAS 94198-40-0)
- 5-(1-Phenylethyl)imidazolidine-2,4-dione (CAS 127675-86-9)
- 2-Methyl-5-nitrobenzyl methanesulfonate (CAS 409082-10-6)
- 2,2＇-Dihydroxy-4-methoxybenzophenone (CAS 131-53-3)
- Prolactin-Releasing Peptide (12-31), rat (CAS 222988-10-5)
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