3-Amino-6-ethyl-N-[4-(trifluoromethyl)phenyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide CAS 445268-98-4
| CAS No. | 445268-98-4 |
| Molecular Formula | C21H20F3N3OS |
| Molecular Weight | 419.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Amino-6-ethyl-N-[4-(trifluoromethyl)phenyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide is closely related to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 3-Amino-6-ethyl-N-[4-(trifluoromethyl)phenyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide (CAS 445268-98-4), a certified reference material (molecular formula C21H20F3N3OS, MW 419.46 g/mol) for analytical method development and quality control.
Structurally, 3-Amino-6-ethyl-N-[4-(trifluoromethyl)phenyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide (C21H20F3N3OS) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 419.46 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20F3N3OS |
| Molecular Weight | 419.46 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-6-ethyl-N-[3-(trifluoromethyl)phenyl]-5H,6H,7H,8H-thieno[2,3-b]quinoline-2-carboxamide (CAS 445269-06-7)
- 3-Amino-N-(2-(trifluoromethyl)phenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide (CAS 445384-39-4)
- 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-(phenethylthio)-1,9-dihydro-6H-purin-6-one (CAS 957046-15-0)
- (E)-7-(3-(2-Amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 878592-87-1)
- N-(2-(2-Amino-5-methylthiazol-4-yl)-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide (CAS 886494-46-8)
- 3-Amino-N-(4-methyl-1,3-oxazol-2-yl)-6-(pyridin-4-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 626225-38-5)
- 4-Amino-5-benzoyl-2-((2,4-dichlorobenzyl)thio)thiophene-3-carbonitrile (CAS 478081-52-6)
- 4-Amino-5-benzoyl-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-3-carbonitrile (CAS 478081-53-7)
Recommended Standards
- 2-((3-Cyano-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 296798-05-5)
- N-Benzyl-2-{[3-cyano-4-(trifluoromethyl)-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-2-yl]sulfanyl}acetamide (CAS 626227-49-4)
- (5E)-3-[(4-tert-Butylphenyl)methyl]-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione (CAS 866152-71-8)
- N-Benzyl-2-{[3-cyano-6-methyl-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-2-yl]sulfanyl}acetamide (CAS 626228-73-7)
- Fluorescein-diacetate-5-isothiocyanate (CAS 118378-76-0)
- 2-(4-Methoxy-3-nitrophenoxy)acetic acid (CAS 90721-77-0)
- 1-[2-(5-Pyrimidinyl)phenyl]ethanone (CAS 893739-49-6)
- 3-{[(3-Fluorobenzyl)oxy]methyl}-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride (CAS 1332529-63-1)
- 5-(2-Aminoethyl)thiophene-2-sulfonamide (CAS 109213-13-0)
- 3,4,5,6-Tetrahydrophthalic anhydride (CAS 2426-02-0)
- 5-phenyl-2-thiophenecarboxaldehyde (CAS 19163-21-4)
- 6-Hydroxy-2-[(4-methoxyphenyl)methylidene]-2,3-dihydro-1-benzofuran-3-one (CAS 20727-61-1)
- (2-Methylpyrazolo[1,5-a]pyrimidin-3-yl)methanol (CAS 1159983-06-8)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com