4-Amino-5-benzoyl-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-3-carbonitrile CAS 478081-53-7

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Amino-5-benzoyl-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-3-carbonitrile.

CATO supplies 4-Amino-5-benzoyl-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-3-carbonitrile (CAS 478081-53-7), a certified reference material (molecular formula C19H12Cl2N2OS2, MW 419.35 g/mol) for analytical method development and quality control.

Owing to a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, 4-Amino-5-benzoyl-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}thiophene-3-carbonitrile is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 419.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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