3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide CAS 445269-12-5
| CAS No. | 445269-12-5 |
| Molecular Formula | C22H25N3O3S |
| Molecular Weight | 411.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 411.52 g/mol gives 3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 445269-12-5), molecular formula C22H25N3O3S and molecular weight 411.52 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (C22H25N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25N3O3S |
| Molecular Weight | 411.52 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 3-Amino-N-(3,4-dimethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 445269-07-8)
- N-(4-amino-2-methylÂquinolin-6-yl)-2-(4-ethylÂphenoxyÂmethylÂ)-benzÂamide (CAS 244218-93-7)
- N-(2-((2-Amino-2-oxoethyl)thio)-4-phenylthiazol-5-yl)-4-phenylbutanamide (CAS 946211-04-7)
- 2-AMINO-1-[2-(4-FLUOROPHENYL)-3-[(4-FLUOROPHENYL)AMINO]-5,6-DIHYDRO-8,8-DIMETHYLIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL]ETHANONE (CAS 1261113-96-5)
- 5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-(4-fluorophenyl)-1,2-dihydro-3h-pyrrol-3-one (CAS 885458-12-8)
- 3-Amino-6-ethyl-N-(4-fluorobenzyl)-5-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 674805-23-3)
- 3-Amino-6-[(3,4-dimethoxyphenyl)methyl]-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 936080-63-6)
- (S)-2-(4-(6-Amino-3-oxobenzo[e][1,2,4]triazin-2(3H)-yl)benzamido)pentanedioic acid (CAS 122712-57-6)
Recommended Standards
- 3-(2-Cyano-4,5-dimethoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]thiourea (CAS 343375-05-3)
- 2-{[5-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893726-65-3)
- 2-Cyclopentyl-N-(3-((4-(4-fluorophenyl)piperazin-1-yl)sulfonyl)propyl)acetamide (CAS 1049342-52-0)
- 1-(4-Chlorophenyl)-3-(dibromomethyl)isoquinoline (CAS 89242-42-2)
- tert-Butyl 2-bromo-6,7-dihydrofuro[3,2-c]pyridine-5(4H)-carboxylate (CAS 1211538-77-0)
- 2,5-Dichloro-3-(2-methylphenyl)propiophenone (CAS 898789-99-6)
- 2,5-Bis(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thiophene (CAS 646998-76-7)
- N-palmitoyltaurine (CAS CATO-C3D-262435)
- Methyl 6-(Methylthio)pyridine-2-carboxylate (CAS 74470-41-0)
- o7-Tert-butylo3-ethyl1-oxa-2,7-diazaspiro[4.4]non-2-ene-3,7-dicarboxylate (CAS 1824081-61-9)
- (1-(4-Fluoro-2-methylphenyl)-1H-pyrazol-4-yl)boronic acid (CAS 2225171-90-2)
- Methyl 2-amino-2-(3,4-dimethylphenyl)acetate (CAS 750563-26-9)
- Tert-butyl (2-(5-formylthiophen-2-yl)phenyl)carbamate (CAS 886509-43-9)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
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