1-Bromo-3-(1,1-difluoroethyl)benzene CAS 445303-70-8
| CAS No. | 445303-70-8 |
| Molecular Formula | C8H7BrF2 |
| Molecular Weight | 221.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Bromo-3-(1,1-difluoroethyl)benzene (CAS 445303-70-8) is a high-purity analytical reference standard with the molecular formula C8H7BrF2 and a molecular weight of 221.04 g/mol.
The molecular framework of 1-Bromo-3-(1,1-difluoroethyl)benzene (C8H7BrF2) is characterized by fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Bromo-3-(1,1-difluoroethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7BrF2 |
| Molecular Weight | 221.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- (2-Bromo-1,1-difluoroethyl)benzene (CAS 108661-89-8)
- 1-(2-bromo-1-fluoroethyl)-4-fluorobenzene (CAS 118887-66-4)
- 5-Bromo-2-(difluoromethyl)toluene (CAS 1254034-33-7)
- 4-Bromo-3-(difluoromethyl)toluene (CAS 1261442-36-7)
- 2-Bromo-1-(difluoromethyl)-3-methylbenzene (CAS 1261552-75-3)
- 1-Bromo-4-(difluoromethyl)-2-methylbenzene (CAS 1261570-11-9)
- 2-Bromo-6-(difluoromethyl)toluene (CAS 1261609-97-5)
- 1-Bromo-2-(difluoromethyl)-3-methylbenzene (CAS 1261642-37-8)
Recommended Standards
- 1-Bromo-2-(1,1-difluoroethyl)benzene (CAS 444581-46-8)
- 1-Bromo-4-ethyl-2,3-difluoro-benzene (CAS 928304-50-1)
- 1-(BROMOMETHYL)-4-(DIFLUOROMETHYL)BENZENE (CAS 873373-34-3)
- 2-(1-Bromoethyl)-1,4-difluorobenzene (CAS 655-10-7)
- 3H-Imidazo[4,5-b]pyridin-7-amine dihydrochloride (CAS 1087700-51-3)
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- 5-(6-Amino-9H-purin-9-yl)pentane-1,3-diol (CAS 69895-62-1)
- 3-Hydroxy-4-(phenethylamino)tetrahydrothiophene 1,1-dioxide (CAS 347364-75-4)
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