4-Bromo-2-(1,1-difluoroethyl)-1-fluorobenzene CAS 445303-71-9
| CAS No. | 445303-71-9 |
| Molecular Formula | C8H6BrF3 |
| Molecular Weight | 239.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Bromo-2-(1,1-difluoroethyl)-1-fluorobenzene (C8H6BrF3) is characterized by fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-Bromo-2-(1,1-difluoroethyl)-1-fluorobenzene (CAS 445303-71-9), molecular formula C8H6BrF3 and molecular weight 239.03 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BrF3 |
| Molecular Weight | 239.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 1-Bromo-2-(2,2,2-trifluoroethyl)benzene (CAS 1027513-81-0)
- 2-Bromo-1-methyl-3-(trifluoromethyl)benzene (CAS 1099597-98-4)
- 2-Bromo-4-(1,1-difluoroethyl)-1-fluorobenzene (CAS 1138444-85-5)
- 2-Bromo-1-(1,1-difluoroethyl)-4-fluorobenzene (CAS 1138444-86-6)
- 2-Bromo-4-methyl-1-(trifluoromethyl)benzene (CAS 121793-12-2)
- 1-Bromo-3-(1,1-difluoroethyl)-2-fluorobenzene (CAS 1313426-10-6)
- 1-Bromo-4-(2,2,2-trifluoroethyl)benzene (CAS 155820-88-5)
- 1-Bromo-4-(1,1-difluoroethyl)-2-fluorobenzene (CAS 1628808-31-0)
Recommended Standards
- 4,6-Dichloro-2-fluoro-3-methoxybenzoic acid (CAS 2365420-17-1)
- 4-Bromo-2-methyl-1-(trifluoromethyl)benzene (CAS 936092-88-5)
- 3-Bromo-5-(trifluoromethyl)toluene (CAS 86845-28-5)
- 5-Bromo-1-(difluoromethyl)-2-fluoro-3-methylbenzene (CAS 2092765-80-3)
- trans-2,6-Diethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (CAS 1003843-31-9)
- 1-(6-Methylbenzo[d]thiazol-2-yl)guanidine (CAS 86328-44-1)
- Methyl 6-(2,6-difluoro-3-methylphenyl)picolinate (CAS 1210419-50-3)
- 2-(3-(Pentafluoro-lambda6-sulfanyl)phenyl)acetic acid (CAS 1211578-68-5)
- 1-fluoronaphthalen-2-amine (CAS 14554-00-8)
- Mianserin lmpurity 31 HCl (CAS CATO-C4X-136931)
- 8-Chloro-5-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-44-5)
- tert-Butyl 3-(3-amino-1H-pyrazol-5-yl)azetidine-1-carboxylate (CAS 1346674-11-0)
- 2-(4-Fluorophenyl)-4-((4-fluorophenyl)sulfonyl)-5-(methylsulfonyl)oxazole (CAS 891021-34-4)
- Exenatide (CAS 141758-74-9（free base）)
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