2-Chloro-3-fluoroanisole CAS 446-60-6
| CAS No. | 446-60-6 |
| Molecular Formula | C7H6ClFO |
| Molecular Weight | 160.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 160.57 g/mol gives 2-Chloro-3-fluoroanisole distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-Chloro-3-fluoroanisole (CAS 446-60-6) is a high-purity analytical reference standard with the molecular formula C7H6ClFO and a molecular weight of 160.57 g/mol.
Structurally, 2-Chloro-3-fluoroanisole (C7H6ClFO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 160.57 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClFO |
| Molecular Weight | 160.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-1-fluoro-2-methoxybenzene (CAS 1092349-89-7)
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- 4-Chloro-2-fluoro-3-methylphenol (CAS 1351668-24-0)
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Recommended Standards
- 1-(Chloromethoxy)-4-fluorobenzene (CAS 34888-02-3)
- 2-Chloro-3-fluorobenzyl Alcohol (CAS 96516-32-4)
- 1-(Chloromethoxy)-3-fluorobenzene (CAS 34888-01-2)
- 2-Chloro-4-fluorobenzyl Alcohol (CAS 208186-84-9)
- 4-(Hydroxymethyl)piperidine-1-carboxamide (CAS 1183956-15-1)
- Bis(4-hydroxyphenyl) Sulfone (CAS 80-09-1)
- 2-(Difluoromethyl)-4-fluoro-6-hydroxypyridine-3-carboxylic acid (CAS 1805190-04-8)
- 6H,6H-Perfluoroundecane-5,7-dione (CAS 261503-82-6)
- Ethyl (s)-2-(pyridin-3-yl)pyrrolidine-1-carboxylate (CAS 69730-90-1)
- 5,7-Dichlorobenzo[c][1,2,5]thiadiazol-4-amine (CAS 16407-86-6)
- 4-[(tert-Butyldimethylsilyl)oxy]-2,3-difluorophenol (CAS 1881289-55-9)
- 2-(1h-Pyrrol-1-yl)cyclohexane-1-carboxylic acid (CAS 1342356-36-8)
- 1-Bromo-4-fluoro-2-thiocyanatobenzene (CAS 2149597-74-8)
- (Ser(PO?H?)3??·???)-Tau Peptide (379-408) trifluoroacetate salt (CAS 2022956-60-9)
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