2-Fluoro-6-methoxyaniline CAS 446-61-7
| CAS No. | 446-61-7 |
| Molecular Formula | C7H8FNO |
| Molecular Weight | 141.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Fluoro-6-methoxyaniline (C7H8FNO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-Fluoro-6-methoxyaniline (CAS 446-61-7), a certified reference material (molecular formula C7H8FNO, MW 141.14 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-6-methoxyaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8FNO |
| Molecular Weight | 141.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 2-(6-Fluoro-3-pyridyl)ethanol (CAS 1000549-35-8)
- 2-Fluoro-4-(methylamino)phenol (CAS 115602-79-4)
- 2-Fluoro-3-methoxy-5-methylpyridine (CAS 1184172-54-0)
- 2-Fluoro-3-methoxy-6-methylpyridine (CAS 1211534-01-8)
- 2-Fluoro-4-methoxy-6-methylpyridine (CAS 1227511-44-5)
- 2-Fluoro-4-methoxy-5-methylpyridine (CAS 1227513-84-9)
- 2-Fluoro-3-(hydroxymethyl)-5-methylpyridine (CAS 1227565-23-2)
- 2-Fluoro-4-methylpyridine-3-methanol (CAS 1227574-63-1)
Recommended Standards
- 2-Fluoro-5-methoxyaniline (CAS 62257-15-2)
- 3-Ethoxy-2-fluoropyridine (CAS 847225-55-2)
- 2-Fluoro-5-(methylamino)phenol (CAS 904321-09-1)
- 3-Fluoro-2-(methoxymethyl)pyridine (CAS 2404734-45-6)
- (R)-3-((tert-Butoxycarbonyl)amino)pyrrolidine-3-carboxylic acid (CAS 2173637-53-9)
- (2-Methylpentyl)({[1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl})amine dihydrochloride (CAS 1240527-76-7)
- N-(9-oxo-9H-fluoren-4-yl)acetamide (CAS 42135-35-3)
- Mitiglinide impurity 26 (CAS CATO-C4X-116126)
- 3-Amino-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (CAS 1684425-51-1)
- 5-Hydroxy-2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromene-6-carboxylic acid (CAS 20408-52-0)
- 7-Chloro-1-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1820707-60-5)
- (Z)-N-(4-Chlorophenyl)-1-[(4-cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]methanecarbohydrazonoyl cyanide (CAS 338976-83-3)
- 6-{[(4-chlorophenyl)sulfanyl]methyl}-2-{[(4-fluorophenyl)methyl]sulfanyl}pyrimidin-4-ol (CAS 860609-65-0)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
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