2-Amino-8-bromo-6-nitroquinazolin-4(1H)-one CAS 447415-80-7
| CAS No. | 447415-80-7 |
| Molecular Formula | C8H5BrN4O3 |
| Molecular Weight | 285.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Amino-8-bromo-6-nitroquinazolin-4(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Amino-8-bromo-6-nitroquinazolin-4(1H)-one (CAS 447415-80-7) is a high-purity analytical reference standard with the molecular formula C8H5BrN4O3 and a molecular weight of 285.05 g/mol.
2-Amino-8-bromo-6-nitroquinazolin-4(1H)-one (C8H5BrN4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5BrN4O3 |
| Molecular Weight | 285.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Amino Standards
- 2-Amino-6-bromo-8-nitroquinazolin-4(3H)-one (CAS 130148-54-8)
- 3-Amino-6-bromo-5-(trifluoromethyl)picolinic acid (CAS 1334546-32-5)
- 3-Amino-5-bromo-6-methoxybenzofuran-2-carboxamide (CAS 1379779-24-4)
- Ethyl 2-amino-7-bromo-1,3-benzoxazole-5-carboxylate (CAS 1820687-34-0)
- Ethyl 3-amino-7-bromofuro[3,2-c]pyridine-2-carboxylate (CAS 2091217-61-5)
- Ethyl 4-amino-3-bromo-5-cyano-2-hydroxybenzoate (CAS 85946-11-8)
- Ethyl 4-amino-7-bromopyrrolo[2,1-f][1,2,4]triazine-5-carboxylate (CAS 1338050-96-6)
- 4-Amino-5-bromo-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde (CAS 1443531-66-5)
Recommended Standards
- 2-(4,5-Difluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2377611-58-8)
- 6-Bromo-4-hydroxy-3-nitroquinolin-2(1H)-one (CAS 54675-38-6)
- 2-(3,5-Difluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2377610-72-3)
- 6-Bromopyrazolo[1,5-a]pyridine-3,4-dicarboxylic acid (CAS 2767590-08-7)
- 2-{4-[3-(trifluoromethyl)benzenesulfonamido]phenyl}acetic acid (CAS 735305-35-8)
- Methyl 2-(bromomethyl)-3-(trifluoromethyl)benzoate (CAS 346603-68-7)
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