2-Methoxy-4-(trifluoromethyl)benzoic Acid CAS 448-36-2
| CAS No. | 448-36-2 |
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Methoxy-4-(trifluoromethyl)benzoic Acid (CAS 448-36-2) is a high-purity analytical reference standard with the molecular formula C9H7F3O3 and a molecular weight of 220.15 g/mol.
2-Methoxy-4-(trifluoromethyl)benzoic Acid (C9H7F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Methoxy-4-(trifluoromethyl)benzoic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Methoxy Standards
- 2-Methoxy-6-(trifluoromethyl)benzoic Acid (CAS 119692-41-0)
- 3-Methoxy-2-(trifluoromethyl)benzoic acid (CAS 1214384-93-6)
- 3-Methoxy-4-(trifluoromethoxy)benzaldehyde (CAS 1261483-00-4)
- 2-Methoxy-3-(trifluoromethoxy)benzaldehyde (CAS 1261748-65-5)
- 2-Methoxy-6-(trifluoromethoxy)benzaldehyde (CAS 1261854-31-2)
- 5-Methoxy-2-(trifluoromethoxy)benzaldehyde (CAS 1261865-44-4)
- 4-Methoxy-2-(trifluoromethyl)benzoic acid (CAS 127817-85-0)
- 2-Methoxy-5-(trifluoromethoxy)benzaldehyde (CAS 145742-65-0)
Recommended Standards
- 2-Methoxy-4-(trifluoromethoxy)benzaldehyde (CAS 886500-13-6)
- 2-Methoxy-5-(trifluoromethyl)benzoic acid (CAS 4864-01-1)
- 2-Methoxy-3-(trifluoromethyl)benzoic acid (CAS 937068-58-1)
- 2-Methyl-4-(trifluoromethoxy)benzoic acid (CAS 261951-91-1)
- 3-((8-Methoxy-6-methylquinolin-4-yl)amino)benzoic acid (CAS 1315373-28-4)
- Tetrahydro-2H-thiopyran-4-carbonyl chloride 1,1-dioxide (CAS 841301-53-9)
- Methyl 2,4-dibromo-3,6-difluorophenylacetate (CAS 1803783-44-9)
- 6-(Pyridin-4-yl)pyridine-2-carboxylic acid (CAS 1214327-06-6)
- 1-Chloroisoquinoline-5-carbaldehyde (CAS 223671-52-1)
- 1,2-Bis((2R,5R)-2,5-diethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate (CAS 136705-70-9)
- Maprotiline EP impurity B HCl (CAS 2724727-05-1)
- 1-(4-Methyl-6-(piperazin-1-yl)pyridin-3-yl)ethanol (CAS 1355179-15-5)
- Methyl 4-(6-amino-9h-purin-9-yl)butanoate (CAS 23124-18-7)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
Why CATO?
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