5-Chloro-2-(trifluoromethoxy)nitrobenzene CAS 448-38-4
| CAS No. | 448-38-4 |
| Molecular Formula | C7H3ClF3NO3 |
| Molecular Weight | 241.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 5-Chloro-2-(trifluoromethoxy)nitrobenzene (CAS 448-38-4), a certified reference material (molecular formula C7H3ClF3NO3, MW 241.55 g/mol) for analytical method development and quality control.
The molecular framework of 5-Chloro-2-(trifluoromethoxy)nitrobenzene (C7H3ClF3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 5-Chloro-2-(trifluoromethoxy)nitrobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF3NO3 |
| Molecular Weight | 241.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-Chloro-2-(difluoromethoxy)-5-fluoro-4-nitrobenzene (CAS 106969-10-2)
- 1-Chloro-4-nitro-2-(trifluoromethoxy)benzene (CAS 113421-97-9)
- 4-CHloro-2-nitro-5-(trifluoromethyl)phenol (CAS 1192021-48-9)
- 4-CHloro-2-nitro-3-(trifluoromethyl)phenol (CAS 1192021-50-3)
- 2-Chloro-5-(trifluoromethoxy)isonicotinic acid (CAS 1221171-77-2)
- 6-Chloro-3-(trifluoromethoxy)picolinic acid (CAS 1221171-83-0)
- 6-Chloro-5-(trifluoromethoxy)picolinic acid (CAS 1221171-90-9)
- 6-Chloro-2-(trifluoromethoxy)nicotinic acid (CAS 1221171-91-0)
Recommended Standards
- 4-(bromomethyl)-2-chloro-1-methoxybenzene (CAS 320407-92-9)
- 5-Chloro-4-nitro-2-(trifluoromethyl)phenol (CAS 2387068-52-0)
- 2-Chloro-6-nitro-4-(trifluoromethyl)phenol (CAS 69741-64-6)
- 8-Bromooctanoyl chloride (CAS 73674-09-6)
- 2,6-difluoro-4-iodo-pyridine-3-carbaldehyde (CAS 2417489-94-0)
- 5-Bromo-2-chloro-3-iodopyridine 928653-73-0 5-Bromo-2-chloro-3-iodo-pyridine (CAS 928653-73-0)
- tert-Butyl 3-hydroxy-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate (CAS 1802180-16-0)
- Tert-butyl 4-oxo-8-oxa-2-azaspiro[4.5]Decane-2-carboxylate (CAS 2126162-41-0)
- 1-Methyl-3,4-dihydro-2H-pyrrol-1-ium (CAS 16032-02-3)
- 2,3-Dibromopropionamide (CAS 15102-42-8)
- N-benzyl-1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 338783-31-6)
- 1-methoxyhexan-2-one (CAS 57134-36-8)
- 4-Methyl-2-(4-(pentyloxy)phenyl)pyrrolidine (CAS 603089-64-1)
- Peptide 441 (CAS CATO-CPTD788441)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com