2-(2-Chloro-4-sulfamoylphenoxy)acetic acid CAS 4486-67-3
| CAS No. | 4486-67-3 |
| Molecular Formula | C8H8ClNO5S |
| Molecular Weight | 265.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-Chloro-4-sulfamoylphenoxy)acetic acid (CAS 4486-67-3), molecular formula C8H8ClNO5S and molecular weight 265.67 g/mol, is a CATO reference standard with documented purity and traceability.
2-(2-Chloro-4-sulfamoylphenoxy)acetic acid (C8H8ClNO5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO5S |
| Molecular Weight | 265.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
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- N-(3-CHloro-4-fluorophenyl)-3-hydroxybenzamide (CAS 1039809-17-0)
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Recommended Standards
- 1-(2-Chloro-6-fluorobenzyl)-6-oxo-1,6-dihydropyridine-3-carbaldehyde (CAS 952183-37-8)
- 2-(4-Chloro-2-sulfamoylphenoxy)acetic acid (CAS 4486-75-3)
- (4-Methoxy-3-nitrophenyl)methanesulfonyl chloride (CAS 6378-24-1)
- 2-(4-Chloro-3-fluorophenoxy)benzaldehyde oxime (CAS 451485-70-4)
- 1-Bromo-3-(bromomethyl)-4-fluoro-2-(trifluoromethyl)benzene (CAS 2091622-35-2)
- 2-({1-[(2,6-dichlorophenyl)methyl]-4-formyl-3-methyl-1H-pyrazol-5-yl}sulfanyl)acetic acid (CAS 882229-32-5)
- 8-((Trimethylsilyl)ethynyl)quinoline (CAS 895164-50-8)
- Barnidipine Hydrochloride (CAS 104757-53-1)
- 5-Bromo-3-methoxypicolinic acid (CAS 1142191-66-9)
- 2,5,6-Trichloronicotinamide (CAS 142266-62-4)
- [4-Fluoro-3-(piperidin-1-ylmethyl)phenyl]boronic acid (CAS 1200131-35-6)
- 6,7-Dimethylquinoxaline (CAS 7153-23-3)
- Beraprost Impurity 23 (CAS 474070-63-8)
- Tetrapeptide-3 (CAS 827306-97-8)
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