4-(4-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one CAS 449-81-0
| CAS No. | 449-81-0 |
| Molecular Formula | C16H10FNO2 |
| Molecular Weight | 267.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-(4-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-(4-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one (CAS 449-81-0) is a high-purity analytical reference standard with the molecular formula C16H10FNO2 and a molecular weight of 267.25 g/mol.
The molecular framework of 4-(4-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one (C16H10FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H10FNO2 |
| Molecular Weight | 267.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorobenzylidene Standards
- 4-(2-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one (CAS 397-60-4)
- 4-(3-Fluorobenzylidene)-2-phenyloxazol-5(4H)-one (CAS 397-62-6)
- 3-Acetyl-5-(4-Fluorobenzylidene)-4-Hydroxy-2(5H)-Thiophenone (CAS 5518-90-1)
- (2Z)-2-(4-Fluorobenzylidene)-6-hydroxy-7-methyl-1-benzofuran-3(2H)-one (CAS 1092298-07-1)
- (Z)-2-(2-fluorobenzylidene)-6-hydroxy-7-methylbenzofuran-3(2H)-one (CAS 1092298-11-7)
- 2-(4-Fluorobenzylidene)-6-methoxybenzofuran-3(2H)-one (CAS 646996-27-2)
- (E)-4-(2-(4-fluorobenzylidene)hydrazinyl)thieno[2,3-d]pyrimidine (CAS 478248-68-9)
- (Z)-2-(3-fluorobenzylidene)-6-hydroxybenzofuran-3(2h)-one (CAS 1353119-32-0)
Recommended Standards
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