2-((4-Nitrobenzyl)thio)quinazolin-4(3h)-one CAS 449745-74-8
| CAS No. | 449745-74-8 |
| Molecular Formula | C15H11N3O3S |
| Molecular Weight | 313.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((4-Nitrobenzyl)thio)quinazolin-4(3h)-one.
2-((4-Nitrobenzyl)thio)quinazolin-4(3h)-one (CAS 449745-74-8), molecular formula C15H11N3O3S and molecular weight 313.33 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-((4-Nitrobenzyl)thio)quinazolin-4(3h)-one (C15H11N3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 313.33 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-((4-Nitrobenzyl)thio)quinazolin-4(3h)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H11N3O3S |
| Molecular Weight | 313.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Nitrobenzyl Standards
- 2-((4-Nitrobenzyl)thio)-5-phenyl-1,3,4-oxadiazole (CAS 116987-25-8)
- 3-{[(4-Nitrobenzyl)oxy]imino}-N-phenylpropanamide (CAS 303996-40-9)
- 4-{5-[(4-Nitrobenzyl)sulfanyl]-1,3,4-oxadiazol-2-yl}pyridine (CAS 441289-28-7)
- 1-Benzyl-4-(4-nitrobenzyl)piperazine (CAS 148120-37-0)
- (1-Methyl-2-((4-nitrobenzyl)sulfonyl)-1H-imidazol-5-yl)methanol (CAS 478049-30-8)
- 10-(4-Nitrobenzyl)-1,4,7-trioxa-10-azacyclododecane (CAS 300359-71-1)
- O-(2-Nitrobenzyl)-L-tyrosine (CAS 184591-51-3)
- 3-((4-Nitrobenzyl)oxy)benzo[b]thiophene-2-carbonitrile (CAS 303985-58-2)
Recommended Standards
- 18A (CAS 331261-50-8)
- 2-((5-(4-Fluorobenzamido)-1,3,4-thiadiazol-2-yl)thio)acetic acid (CAS 329695-55-8)
- 1-(4-Fluorophenyl)-4-{3-methyl-[1,2]oxazolo[5,4-d]pyrimidin-4-yl}piperazine (CAS 478062-74-7)
- 2-(4-Acetoxyphenyl)benzo[d]thiazole-6-carboxylic acid (CAS 293762-52-4)
- 2-(4-Bromo-6-(difluoromethyl)-5-fluoropyridin-3-yl)acetic acid (CAS 1804884-27-2)
- 4-(5,5-Dimethyl-1,3-dioxan-2-yl)-4-methoxybutyrophenone (CAS 898786-45-3)
- BENZYL 2-ACETYLPHENYLCARBAMATE (CAS 314773-75-6)
- 1-O,2-O,3-O,4-O-Bis(1-methylethylidene)-6-deoxy-L-arabino-5-hexenopyranose (CAS 22618-03-7)
- 5,6-Diethyl-3-oxo-2,3-dihydropyridazine-4-carbothioamide (CAS 1394042-01-3)
- 4-Bromo-1-(1-methoxy-2-methylpropan-2-yl)-1H-pyrazole (CAS 2306263-91-0)
- 2-(4-Fluoro-1H-pyrazol-1-yl)ethanol (CAS 1207961-59-8)
- 3-(4-(Dimethoxymethyl)pyrimidin-2-yl)propan-1-amine (CAS 944900-74-7)
- 3-Ethyl-6-methylpyridin-2-amine (CAS 41995-31-7)
- Biotinyl-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802086-28-7)
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