6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride CAS 449808-64-4
| CAS No. | 449808-64-4 |
| Molecular Formula | C19H18F2N4O3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride (CAS 449808-64-4) is a high-purity analytical reference standard with the molecular formula C19H18F2N4O3HCl and a molecular weight of 424.83 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 424.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 6-(2,4-Difluorophenoxy)-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18F2N4O3 HCl |
| Molecular Weight | 424.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Difluorophenoxy Standards
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- Methyl 1-((2,4-difluorophenoxy)methyl)-1h-pyrazole-3-carboxylate (CAS 1004193-81-0)
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Recommended Standards
- 4-Chloro-2-cyclopentyl-6-methylpyrimidine (CAS 1111832-72-4)
- 3-Chloro-2-[1-(2-chlorobenzoyl)-4,5-dihydro-1H-1,2,3,4-tetrazol-5-yl]-5-(trifluoromethyl)pyridine (CAS 1092345-83-9)
- 2,2,2-Trichloro-1-(4-(2,4-dichlorobenzoyl)-1H-pyrrol-2-yl)ethan-1-one (CAS 303995-92-8)
- Neuromedin U-8 (porcine) (CAS 98395-75-6)
- (3R,5S,Z)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt (CAS 1444772-08-0)
- Lumateperone Impurity N5 (CAS 313368-81-9)
- Ethyl 3-[(2,2-diethoxyethyl)amino]propanoate (CAS 1221341-37-2)
- 2-Amino-6-bromo-4-fluorobenzothiazole 2-benzothiazolamine, 6-bromo-4-fluoro- 383131-45-1 6-bromo-4-fluoro-1,3-benzothiazol-2-amine (CAS 383131-45-1)
- Ethyl L-pyroglutamate (CAS 7149-65-7)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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