4-(4-Fluorophenyl)-2-methylthiazole CAS 450-29-3
| CAS No. | 450-29-3 |
| Molecular Formula | C10H8FNS |
| Molecular Weight | 193.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution, 4-(4-Fluorophenyl)-2-methylthiazole is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 193.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-(4-Fluorophenyl)-2-methylthiazole (CAS 450-29-3) is a high-purity analytical reference standard with the molecular formula C10H8FNS and a molecular weight of 193.24 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8FNS |
| Molecular Weight | 193.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Fluorophenyl Standards
- 1-((4-Fluorophenyl)thio)cyclopropane-1-carbonitrile (CAS 103574-79-4)
- 4-(2-Fluorophenyl)-2-methylthiazole (CAS 1355248-06-4)
- 4-(3-Fluorophenyl)thiophen-2-amine (CAS 1392042-84-0)
- 2-(2-Fluorophenyl)thiophen-3-amine (CAS 1512747-39-5)
- 2-(4-Fluorophenyl)thiophen-3-amine (CAS 183677-10-3)
- 2-(3-Fluorophenyl)thiophen-3-amine (CAS 183677-11-4)
- 1-Ethyl-2-(4-fluorophenyl)pyrrolidine (CAS 1109231-05-1)
- 3-(4-fluorophenyl)-2,2-dimethylpyrrolidine (CAS 1247532-68-8)
Recommended Standards
- 4-(3-Methylmorpholin-2-yl)phenol (CAS 54804-09-0)
- 4-(4-Methoxyphenyl)-2-butanone oxime (CAS 52271-43-9)
- 4-(2-Methoxyphenyl)morpholine (CAS 27347-13-3)
- 4-(4-Methoxyphenyl)butanamide (CAS 2222-15-3)
- N4-Cyclopropyl-N6-(piperidin-2-ylmethyl)pyrimidine-4,6-diamine hydrochloride (CAS 1353956-39-4)
- N-hydroxy-2-thiomorpholino-acetamidine (CAS 883949-22-2)
- N-(6-Ethoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)butyramide (CAS 476295-17-7)
- (4R)-4-Aminopyrrolidin-2-one dihydrochloride (CAS 1909288-00-1)
- (3R)-3-(2-chlorophenoxy)pyrrolidine (CAS 900572-39-6)
- 7-Methyl-5-oxaspiro[3.4]Octan-7-ol (CAS 2306260-97-7)
- 1-(5-Chlorospiro[indoline-3,4'-piperidin]-1-yl)ethanone (CAS 637362-19-7)
- 2-(difluoromethoxy)pyridin-4-amine (CAS 1211587-46-0)
- Trivinylmethylsilane (CAS 18244-95-6)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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