1-Bromo-4-fluoro-2-methoxybenzene CAS 450-88-4
| CAS No. | 450-88-4 |
| Molecular Formula | C7H6BrFO |
| Molecular Weight | 205.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system, 1-Bromo-4-fluoro-2-methoxybenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.02 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-Bromo-4-fluoro-2-methoxybenzene (CAS 450-88-4) is a high-purity analytical reference standard with the molecular formula C7H6BrFO and a molecular weight of 205.02 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6BrFO |
| Molecular Weight | 205.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 3-Bromo-2-fluoro-5-methylphenol (CAS 1026796-51-9)
- 5-Bromo-2-fluoroanisole (CAS 103291-07-2)
- 5-Bromo-2-fluoro-4-methylphenol (CAS 1111096-04-8)
- 3-Bromo-4-fluoroanisole (CAS 1161497-23-9)
- 2-Bromo-3-fluorobenzyl alcohol (CAS 1184915-45-4)
- 2-Bromo-6-fluoro-3-methylphenol (CAS 1226808-63-4)
- 4-Bromo-3-fluoro-2-methylphenol, 97% (CAS 1262516-23-3)
- 2-Bromo-5-fluoro-4-methylphenol (CAS 1268511-85-8)
Recommended Standards
- 1-Bromo-2-methyl-4,4,4-trifluorobutane (CAS 203302-90-3)
- 2-(Bromomethyl)-6-fluorophenol (CAS 872058-42-9)
- (5-Bromo-2-fluorophenyl)methanol (CAS 99725-13-0)
- 2,6-Dichloro-5-fluoro-4-methylnicotinonitrile (CAS 2168342-60-5)
- 25135-51-7 Poly(oxy-1,4-phenylenesulfonyl-1,4-phenyleneoxy-1,4-phenylene(1-methylethylidene)-1,4-phenylene) Reigning NSC 170902 Polysulfone Polysulfone A Polysulphone UDEL Polysulfone P 1700 Reigning resin (CAS 25135-51-7)
- Methyl 2-amino-4-(trifluoromethyl)nicotinate (CAS 1227574-73-3)
- Methyl 2-((2,5-dioxopyrrolidin-3-yl)amino)acetate (CAS 1218133-58-4)
- 1-Methyl-4-(prop-1-en-2-yl)cyclohexane-1-sulfonic acid (CAS 805184-60-5)
- Bucladesine Calcium Salt (CAS 938448-87-4)
- (3R)-1-(Pyrimidin-4-yl)pyrrolidin-3-amine dihydrochloride (CAS 1365936-54-4)
- Piracetam Impurity 22 (CAS 57478-45-2（free base）)
- Atrasentan Impurity 44 (CAS 223139-41-1)
- 3-Fluoro-4-hydroxybenzene-1-carbothioamide (CAS 1153271-82-9)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
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