Osimertinib Impurity 111 CAS 450-84-0
| CAS No. | 450-84-0 |
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 155.13 g/mol gives Osimertinib Impurity 111 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Osimertinib Impurity 111 (CAS 450-84-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6FNO2 and a molecular weight of 155.13 g/mol.
Osimertinib Impurity 111 (C7H6FNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity 111 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molecular Weight | 155.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Osimertinib Standards
- Osimertinib Impurity 13 (CAS 2090542-75-7)
- Osimertinib Impurity 44 (CAS CATO-C4X-204544)
- Osimertinib Impurity 65 (CAS CATO-C4X-204565)
- Osimertinib Impurity 15 (CAS 1896788-06-9)
- Osimertinib Impurity 56 (CAS CATO-C4X-204556)
- Osimertinib Impurity 14 (CAS 2364486-23-5)
- Osimertinib Impurity 28 (CAS 6637-11-2)
- Osimertinib Impurity 107 (CAS CATO-C4X-2045107)
Recommended Standards
- Enzalutamide Impurity 21 (CAS 446-31-1)
- 2-Nitrobenzaldehyde-d (CAS 1020718-69-7)
- 4-Fluoroanthranilic Acid (CAS 446-32-2)
- 4,5-Difluoroindoline (CAS 1159094-25-3)
- Bilastine impurity 122 (CAS 1215537-40-8)
- Trelagliptin Impurity 27 (CAS CATO-C4X-104627)
- Dronedarone Impurity 92 (CAS 141626-35-9)
- 2-(4-((Benzyl(isopropyl)amino)methyl)piperidin-1-yl)ethanol (CAS 1353975-19-5)
- 6-oxabicyclo[3.2.1]octan-2-ylmethanethiol (CAS 2288226-01-5)
- N-Nitroso Rosuvastatin (CAS CATO-C4X-1169211)
- 5,8-Dihydroquinazolin-4(1H)-one (CAS 99966-39-9)
- 3-Benzyl-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyrimidine (CAS 1231943-11-5)
- 80907-56-8 Tris(2,2'-bipyrazine)ruthenium(II) hexafluorophosphate, 95% MFCD27952557 (CAS 80907-56-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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