4-Chloro-2-fluorotoluene CAS 452-75-5
| CAS No. | 452-75-5 |
| Molecular Formula | C7H6ClF |
| Molecular Weight | 144.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-2-fluorotoluene is closely related to fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-Chloro-2-fluorotoluene (CAS 452-75-5), molecular formula C7H6ClF and molecular weight 144.57 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloro-2-fluorotoluene (C7H6ClF) contains fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Chloro-2-fluorotoluene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClF |
| Molecular Weight | 144.57 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-3-fluorotoluene (CAS 116850-28-3)
- 3-Chloro-4-fluorotoluene (CAS 1513-25-3)
- 1-Chloro-3-fluoro-5-methylbenzene (CAS 93857-90-0)
- 2-Chloro-5-fluorotoluene (CAS 33406-96-1)
- 2-Chloro-6-fluorotoluene (CAS 443-83-4)
- 3-Chloro-2-fluorotoluene (CAS 85089-31-2)
- 4-Chloro-3-fluorotoluene (CAS 5527-94-6)
- 5-Chloro-2-fluorotoluene (CAS 452-66-4)
Recommended Standards
- 3-Fluorobenzyl chloride (CAS 456-42-8)
- 2-Fluorobenzyl Chloride (CAS 345-35-7)
- 4-Fluorobenzyl Chloride (CAS 352-11-4)
- 2-Chloro-4-fluorotoluene (CAS 452-73-3)
- 3-{6-cyclopropylimidazo[2,1-b][1,3]thiazol-3-yl}propanoic acid (CAS 1286732-75-9)
- (1-(6-Ethoxypyrimidin-4-yl)piperidin-3-yl)methanamine hydrochloride (CAS 1353984-26-5)
- N-isopropyl-2-(methylamino)acetamide (CAS 51489-14-6)
- 2103-95-9 4-(4-Bromophenyl)-1,3-thiazole-2(3H)-thione DTXSID50499622 (CAS 2103-95-9)
- 1-(2-Chlorophenyl)-1,2,3,4-tetrahydroisoquinoline (CAS 304463-94-3)
- 3-Amino-N-(2-chlorophenethyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 496019-25-1)
- 3-Fluoro-4-methoxy-N-(3-methylbutan-2-yl)aniline (CAS 1096888-17-3)
- 7-Amino-2-cyclobutyl[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile (CAS 1379811-33-2)
- N-{2-[2-(sec-Butyl)phenoxy]propyl}-3-(2-phenoxyethoxy)aniline (CAS 1040686-51-8)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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