2-(trifluoromethoxy)aniline hydrochloride CAS 452077-64-4
| CAS No. | 452077-64-4 |
| Molecular Formula | C7H6F3NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(trifluoromethoxy)aniline hydrochloride (C7H6F3NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 2-(trifluoromethoxy)aniline hydrochloride (CAS 452077-64-4), a certified reference material (molecular formula C7H6F3NOHCl, MW 213.58 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO HCl |
| Molecular Weight | 213.58 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related trifluoromethoxy Standards
- 3-Methyl-5-(trifluoromethoxy)benzaldehyde (CAS 1000339-55-8)
- 1000339-57-0 3-Methyl-5-(trifluoromethoxy)phenylacetic acid MFCD08741405 (CAS 1000339-57-0)
- 3-(4-(Trifluoromethoxy)phenyl)propan-1-ol (CAS 1000519-40-3)
- 2-[4-(Trifluoromethoxy)phenyl]cyclopropan-1-amine (CAS 1001316-74-0)
- 4-(4-(Trifluoromethoxy)phenyl)piperidine hydrochloride (CAS 1004618-85-2)
- 3-Methyl-5-(trifluoromethoxy)cinnamic acid (CAS 1005378-68-6)
- 5-(Trifluoromethoxy)-2-(trifluoromethyl)-1H-indole (CAS 1007235-31-5)
- (4-(Trifluoromethoxy)benzyl)hydrazine 2,2,2-trifluoroacetate (CAS 1007599-47-4)
Recommended Standards
- 5-Methoxy-2-vinyl-1H-benzo[d]imidazole (CAS 1196154-96-7)
- 4-[cyclohexyl(methyl)amino]benzoic acid (CAS 243662-77-3)
- Ethyl 3-chloro-4-hydroxybenzoate (CAS 16357-41-8)
- 3-Phenyl-[1,2,4]triazolo[5,1-c][1,2,4]triazin-4-amine (CAS 521300-68-5)
- 5-(2-Methylprop-1-en-1-yl)-1,3,4-thiadiazol-2-amine (CAS 874507-61-6)
- 5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazole-4-carbaldehyde (CAS 377767-11-8)
- 1-(2-Cyanoethyl)-1H-pyrrole-2-carboxamide (CAS 129053-93-6)
- 4-(Phenylsulfonamido)benzoic acid (CAS 28547-16-2)
- Tolvaptan Impurity 49 (CAS CATO-C4X-195549)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
Why CATO?
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