3-Bromo-5-(trifluoromethoxy)benzoic acid CAS 453565-90-7
| CAS No. | 453565-90-7 |
| Molecular Formula | C8H4BrF3O3 |
| Molecular Weight | 285.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Bromo-5-(trifluoromethoxy)benzoic acid.
3-Bromo-5-(trifluoromethoxy)benzoic acid (CAS 453565-90-7) is a high-purity analytical reference standard with the molecular formula C8H4BrF3O3 and a molecular weight of 285.01 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system, 3-Bromo-5-(trifluoromethoxy)benzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 285.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Bromo-5-(trifluoromethoxy)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4BrF3O3 |
| Molecular Weight | 285.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 4-bromo-3-(trifluoromethoxy)benzoic acid (CAS 1008769-87-6)
- 2-Bromo-4-(trifluoromethoxy)benzoic acid (CAS 1138331-74-4)
- 2-Bromo-3-(trifluoromethoxy)benzoic acid (CAS 1159512-46-5)
- 2-Bromo-5-(trifluoromethoxy)benzoic acid (CAS 403646-48-0)
- 3-Bromo-2-(trifluoromethoxy)benzoic acid (CAS 403646-45-7)
- 3-Bromo-2-hydroxy-5-(trifluoromethoxy)benzaldehyde (CAS 2149601-02-3)
- 3-Bromo-4-(trifluoromethoxy)benzoic acid (CAS 85373-96-2)
- 4-Bromo-2-(trifluoromethoxy)benzoic Acid (CAS 509142-48-7)
Recommended Standards
- 4-Bromo-2-hydroxy-3-(trifluoromethyl)benzoic acid (CAS 2385518-14-7)
- 5-Bromo-2-(trifluoromethoxy)benzoic acid (CAS 403646-47-9)
- 5-Bromo-2-hydroxy-3-(trifluoromethoxy)benzaldehyde (CAS 497959-32-7)
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)benzoic acid (CAS 251300-31-9)
- 6-Bromo-4-chloro-7-methoxyquinazoline (CAS 1256955-27-7)
- 7-Bromo-1H-pyrrolo[3,2-b]pyridin-3-amine (CAS 1190318-37-6)
- 4-Methyl-6-nitro-1H-benzo[d]imidazole (CAS 861600-96-6)
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