Posaconazole Impurity 263 CAS 454479-37-9
| CAS No. | 454479-37-9 |
| Molecular Formula | C24H27F2N5O2 |
| Molecular Weight | 455.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Posaconazole Impurity 263 (CAS 454479-37-9, C24H27F2N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H27F2N5O2, Posaconazole Impurity 263 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 455.50 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Posaconazole Impurity 263 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H27F2N5O2 |
| Molecular Weight | 455.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Posaconazole Standards
- Posaconazole Impurity 10 (CAS 149809-43-8)
- Posaconazole Impurity 11 (CAS 159811-30-0)
- Posaconazole Impurity 139 (CAS CATO-C4X-1208139)
- Posaconazole Impurity 140 (CAS CATO-C4X-1208140)
- Posaconazole Impurity 141 (CAS CATO-C4X-1208141)
- Posaconazole Impurity 142 (CAS CATO-C4X-1208142)
- Posaconazole Impurity 146 (CAS CATO-C4X-1208146)
- Posaconazole Impurity 147 (CAS CATO-C4X-1208147)
Recommended Standards
- Z-Val-Gly-Gly-OBzl (C-2855.0005) (CAS 72722-19-1)
- FA-Gly-Phe-Leu-OH (CAS 390766-88-8)
- 3-((4-Methylbenzyl)thio)-4-phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)-4H-1,2,4-triazole (CAS 383145-78-6)
- Ethyl 5-cyano-4-(3,4-dimethoxyphenyl)-2-methyl-6-(quinolin-2-yl)-1,4-dihydropyridine-3-carboxylate (CAS 10354-39-9)
- Fexofenadine EP Impurity D (CAS 154825-96-4)
- Verteporfin Impurity 7 (CAS CATO-C4X-35497)
- Dasatinib Impurity 19 (CAS CATO-C4X-160719)
- 4-(4-Bromo-3-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 1696800-61-9)
- 6-(3-Chloropropanoyl)benzo[d]oxazol-2(3H)-one (CAS 132383-36-9)
- N-(5-Chloro-2-methoxyphenyl)-N-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 377061-57-9)
- N-((3-Methyl-1,2,4-oxadiazol-5-yl)methyl)-2-(pyrimidin-2-ylamino)thiazole-4-carboxamide (CAS 1251560-10-7)
- 2-Amino-3-(cyclopent-1-en-1-yl)propanoic acid (CAS 90087-65-3)
- Methyl 7-bromoquinoline-2-carboxylate (CAS 1267641-04-2)
- Neuropeptide S (rat) (CAS 412938-75-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com