Cladribine EP Impurity A CAS 4546-70-7
| CAS No. | 4546-70-7 |
| Molecular Formula | C10H14N6O3 |
| Molecular Weight | 266.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Cladribine EP Impurity A (CAS 4546-70-7) is a high-purity analytical reference standard with the molecular formula C10H14N6O3 and a molecular weight of 266.26 g/mol.
The molecular framework of Cladribine EP Impurity A (C10H14N6O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14N6O3 |
| Molecular Weight | 266.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 6 |
Related Cladribine Standards
Recommended Standards
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- Topiroxostat Impurity 11 (CAS CATO-C4X-105511)
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- Topiroxostat Impurity 28 (CAS 1992028-94-0)
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- 1-[3-(morpholine-4-sulfonyl)phenyl]ethan-1-one (CAS 173158-11-7)
- tert-Butyl N-({[4-(benzyloxy)phenyl]carbamoyl}methyl)carbamate (CAS 220741-24-2)
- D-Ser12-Semaglutide (CAS CATO-C4X-2226240)
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