3-Chloro-5-fluoro-4-hydroxybenzoic acid CAS 455-57-2
| CAS No. | 455-57-2 |
| Molecular Formula | C7H4ClFO3 |
| Molecular Weight | 190.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-5-fluoro-4-hydroxybenzoic acid.
3-Chloro-5-fluoro-4-hydroxybenzoic acid (CAS 455-57-2), molecular formula C7H4ClFO3 and molecular weight 190.56 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 3-Chloro-5-fluoro-4-hydroxybenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-5-fluoro-4-hydroxybenzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H4ClFO3 |
| Molecular Weight | 190.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-5-fluoro-4-methyl-3-nitropyridine (CAS 1003711-51-0)
- 5-Chloro-4-fluoro-2-nitroaniline (CAS 104222-34-6)
- 3-Chloro-4-fluoro-2-nitroaniline (CAS 1059081-23-0)
- 5-Chloro-3-fluoro-2-nitroaniline (CAS 1352457-23-8)
- 2-Chloro-5-fluoro-4-hydroxybenzoic acid (CAS 1394954-06-3)
- 2-Chloro-4-fluoro-5-nitroaniline (CAS 139626-20-3)
- Methyl 2-Chloro-5-fluoropyrimidine-4-carboxylate (CAS 1404364-32-4)
- 4-Chloro-2-fluoro-6-nitroaniline (CAS 1482558-25-7)
Recommended Standards
- 3-Chloro-5-fluoro-2-hydroxy-benzoic acid (CAS 4068-62-6)
- 3-Chloro-6-fluoro-2-nitroaniline (CAS 50409-01-3)
- 3-Chloro-4-fluoro-5-hydroxybenzoic acid (CAS 950525-96-9)
- 4-Amino-6-chloro-5-fluoronicotinic acid (CAS 2454491-15-5)
- Carbostyril 124 (CAS 19840-99-4)
- 5-Methoxytetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione (CAS 21730-79-0)
- 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidineHCl (CAS 1187830-71-2)
- 5-Chloro-3-(2-methoxyethoxy)thiophene-2-carboxylic acid (CAS 1708250-98-9)
- (2-Nitrophenyl)(pyrrolidin-1-yl)methanone (CAS 169330-07-8)
- 2-{6-chloroimidazo[1,2-a]pyridin-2-yl}acetic acid (CAS 59128-13-1)
- 3,6-Dibromoimidazo[1,2-a]pyrazine (CAS 1245647-43-1)
- 2,2’-Bipiperidine (CAS 531-67-9)
- 5-Iodobenzofuran-2-carboxylic acid (CAS 1144854-04-5)
- Semaglutide Impurity 163 (x TFA Salt) (CAS CATO-C4X-2226163)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com