Methyl 4-(trifluoromethyl)picolinate CAS 455941-78-3
| CAS No. | 455941-78-3 |
| Molecular Formula | C8H12F3NO2 |
| Molecular Weight | 211.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 4-(trifluoromethyl)picolinate (CAS 455941-78-3), molecular formula C8H12F3NO2 and molecular weight 211.18 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 4-(trifluoromethyl)picolinate (C8H12F3NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 4-(trifluoromethyl)picolinate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12F3NO2 |
| Molecular Weight | 211.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- cis-4-Aminocyclohexyl 2,2,2-trifluoroacetate (CAS 809288-10-6)
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- 5-Chloro-2-methylquinoxaline (CAS 76982-24-6)
- Palmitoyl-L-carnitine Hydrochloride (CAS 18877-64-0)
- 1-(3-Fluorophenyl)prop-2-en-1-ol (CAS 38340-15-7)
- 3-Benzyl-1,2,4-oxadiazol-5-amine (CAS 55654-03-0)
- 2-((1-((Benzyloxy)carbonyl)pyrrolidin-3-yl)thio)acetic acid (CAS 1353957-77-3)
- 3-methanesulfonamido-5-(trifluoromethyl)benzoic acid (CAS 1291361-71-1)
- [3-(4-bromophenyl)-1H-1,2,4-triazol-5-yl]methanamine hydrochloride (CAS 1240527-78-9)
- Palmitoyl hexapeptide-6 (CAS 891498-01-4)
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