3-[(4-fluorophenyl)methoxy]benzoic acid CAS 457-97-6
| CAS No. | 457-97-6 |
| Molecular Formula | C14H11FO3 |
| Molecular Weight | 246.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[(4-fluorophenyl)methoxy]benzoic acid (CAS 457-97-6), molecular formula C14H11FO3 and molecular weight 246.23 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[(4-fluorophenyl)methoxy]benzoic acid (C14H11FO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11FO3 |
| Molecular Weight | 246.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related fluorophenyl Standards
- 2-(5-(2-Fluorophenyl)furan-2-yl)cyclopropanecarboxylic acid (CAS 1315372-59-8)
- 2-(5-(4-Fluorophenyl)furan-2-yl)cyclopropanecarboxylic acid (CAS 1315374-05-0)
- 1-(4-fluorophenyl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid (CAS 123345-03-9)
- Ethyl 2-(3-fluorophenyl)pyrimidine-5-carboxylate (CAS 1240622-63-2)
- Ethyl 2-(2-fluorophenyl)pyrimidine-5-carboxylate (CAS 1245059-88-4)
- Ethyl 2-(4-fluorophenyl)pyrimidine-5-carboxylate (CAS 1245096-92-7)
- 2-(4-Fluorophenyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one (CAS 1956321-33-7)
- 1-(2-Fluorophenyl)-1h,4h,5h,6h-cyclopenta[c]pyrazole-3-carboxylic acid (CAS 926261-73-6)
Recommended Standards
- 3-[(4-fluorophenoxy)methyl]benzoic acid (CAS 869950-21-0)
- 3-Benzyloxy-4-fluorobenzoic acid (CAS 616197-92-3)
- 3-[(2-Fluorophenoxy)methyl]benzoic acid (CAS 944891-81-0)
- 3-Fluoro-2-[(phenylmethyl)oxy]benzoic acid (CAS 938181-74-9)
- Tert-butyl (3aR,8S,8aR)-8-amino-3,3a,8,8a-tetrahydroindeno[1,2-c]pyrrole-2(1H)-carboxylate (CAS 1932779-40-2)
- 9-Bromo-N-(1-iminoethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide (CAS 1628256-47-2)
- Benzyl (4-(2-aminoethyl)phenyl)carbamate (CAS 1139884-44-8)
- 1-Benzyl-N,3,3-trimethylpiperidin-4-amine (CAS 473838-38-9)
- 2-(3-chlorophenyl)-1-methyl-6-oxopiperidine-3-carboxamide (CAS 1333779-45-5)
- 2-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridine-4-carboxylic acid (CAS 1806049-18-2)
- 2-(4-(Difluoromethyl)-2,5-dimethoxypyridin-3-yl)acetonitrile (CAS 1806891-76-8)
- Methyl 1-(methylsulfonamido)cyclopentanecarboxylate (CAS 1706441-94-2)
- 2,3-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 741709-65-9)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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