1-(4-Fluorophenyl)-3-(thiazol-2-yl)thiourea CAS 457-82-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(4-Fluorophenyl)-3-(thiazol-2-yl)thiourea.

1-(4-Fluorophenyl)-3-(thiazol-2-yl)thiourea (CAS 457-82-9) is a high-purity analytical reference standard with the molecular formula C10H8FN3S2 and a molecular weight of 253.32 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution, 1-(4-Fluorophenyl)-3-(thiazol-2-yl)thiourea is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 253.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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