Ethyl 2-amino-3-(3-chloro-4-fluorophenyl)propanoate hydrochloride CAS 457654-57-8
| CAS No. | 457654-57-8 |
| Molecular Formula | C11H13ClFNO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-amino-3-(3-chloro-4-fluorophenyl)propanoate hydrochloride (CAS 457654-57-8), molecular formula C11H13ClFNO2HCl and molecular weight 282.14 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C11H13ClFNO2HCl, Ethyl 2-amino-3-(3-chloro-4-fluorophenyl)propanoate hydrochloride contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 282.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 2-amino-3-(3-chloro-4-fluorophenyl)propanoate hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13ClFNO2 HCl |
| Molecular Weight | 282.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 5471-63-6 InChI=1/C20H14O/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)20(21-19)16-11-5-2-6-12-16/h1-14 (CAS 5471-63-6)
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- 2-Bromo-6-methylphenyl trifluoromethanesulfonate (CAS 1820716-91-3)
- N-(4-Chlorophenyl)-4-{6-methyl-[1,2,4]triazolo[3,2-b][1,3]thiazol-5-yl}-1,3-thiazol-2-amine (CAS 478080-34-1)
- 1-Bromo-3-hydroxypropan-2-one (CAS 38987-72-3)
- Fema3320 (CAS 65505-25-1)
- Fmoc-Pro-Pro-Pro-Pro-Pro-OH (CAS 454693-94-8)
- (4-(Hydroxymethyl)piperidin-1-yl)(2-iodophenyl)methanone (CAS 1178917-65-1)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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