4’-(Trifluoromethyl)biphenyl-4-methanol CAS 457889-46-2
| CAS No. | 457889-46-2 |
| Molecular Formula | C14H11F3O |
| Molecular Weight | 252.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4’-(Trifluoromethyl)biphenyl-4-methanol (CAS 457889-46-2) is a high-purity analytical reference standard with the molecular formula C14H11F3O and a molecular weight of 252.23 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, 4’-(Trifluoromethyl)biphenyl-4-methanol is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 252.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11F3O |
| Molecular Weight | 252.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 3-(Trifluoromethyl)thieno[3,2-b]thiophene-2-carboxylic acid (CAS 1193388-63-4)
- 3-Methyl-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-ol (CAS 1261566-66-8)
- 4’-(Trifluoromethyl)biphenyl-3-methanol (CAS 126485-55-0)
- 8-(trifluoromethyl)quinazoline-4-carboxylic acid (CAS 1781371-03-6)
- 7-(trifluoromethyl)quinazoline-4-carboxylic acid (CAS 1781377-74-9)
- 6-(trifluoromethyl)quinazoline-4-carboxylic acid (CAS 1784635-02-4)
- 6-(trifluoromethyl)quinazoline-2-carboxylic acid (CAS 1784983-74-9)
- (2'-(Trifluoromethyl)-[1,1'-biphenyl]-3-yl)methanol (CAS 885966-08-5)
Recommended Standards
- 4-(Benzyloxy)-1-(difluoromethyl)-2-fluorobenzene (CAS 2149601-32-9)
- 4-Benzyloxybenzotrifluoride (CAS 70097-65-3)
- 4-(5-(Morpholinomethyl)-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-amine (CAS 890094-28-7)
- 5-(1-Amino-2-(1H-1,2,4-triazol-1-yl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 338405-47-3)
- N-(2-Chloro-3-cyclopropoxypyridin-4-yl)methanesulfonamide (CAS 1243409-79-1)
- (2E)-3-[4-(Methylsulfanyl)phenyl]-1-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}prop-2-en-1-one (CAS 329080-32-2)
- (3-Methyl-1,1-dioxidothietan-3-yl)methanesulfonyl chloride (CAS 2091110-80-2)
- 3-Iodo-4-methyl-5-nitro-1H-pyrrolo[2,3-b]pyridine, 97% (CAS 2092716-98-6)
- 6-Bromo-2-(3-ethoxyphenyl)quinoline-4-carboxylic acid (CAS 350999-95-0)
- 4-(2-Bromoethyl)-1,3,5-trimethyl-1h-pyrazole (CAS 1007505-04-5)
- 5-Bromo-2-(phenylamino)benzoic acid (CAS 82762-60-5)
- 6-Bromo-2-chloro-3-methylquinoline (CAS 113092-96-9)
- (S)-(2-(Pyridin-2-yl)-4,5-dihydrooxazol-4-yl)methanol (CAS 1620662-85-2)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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