8-Amino-6-(trifluoromethyl)-3,4-dihydro-2h-1,4-benzoxazin-3-one CAS 459191-31-2
| CAS No. | 459191-31-2 |
| Molecular Formula | C9H7F3N2O2 |
| Molecular Weight | 232.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Amino-6-(trifluoromethyl)-3,4-dihydro-2h-1,4-benzoxazin-3-one (CAS 459191-31-2) is a high-purity analytical reference standard with the molecular formula C9H7F3N2O2 and a molecular weight of 232.16 g/mol.
The molecular framework of 8-Amino-6-(trifluoromethyl)-3,4-dihydro-2h-1,4-benzoxazin-3-one (C9H7F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 8-Amino-6-(trifluoromethyl)-3,4-dihydro-2h-1,4-benzoxazin-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7F3N2O2 |
| Molecular Weight | 232.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-4-(aminomethyl)-5-(trifluoromethoxy)nicotinonitrile (CAS 1804033-18-8)
- 4-Amino-5-(aminomethyl)-2-(trifluoromethoxy)nicotinonitrile (CAS 1806144-26-2)
- 2-(6-Amino-2-(difluoromethyl)-5-methoxypyridin-3-yl)acetic acid (CAS 1805011-75-9)
- 2-(4-Amino-6-(difluoromethyl)-3-methoxypyridin-2-yl)acetic acid (CAS 1805143-52-5)
- 2-(2-Amino-6-(difluoromethyl)-5-methoxypyridin-3-yl)acetic acid (CAS 1805223-65-7)
- 2-(6-Amino-5-(difluoromethyl)-4-methoxypyridin-2-yl)acetic acid (CAS 1805362-45-1)
- 2-(4-Amino-3-(difluoromethyl)-5-methoxypyridin-2-yl)acetic acid (CAS 1805363-33-0)
- 2-(4-Amino-5-(difluoromethyl)-6-methoxypyridin-3-yl)acetic acid (CAS 1806794-89-7)
Recommended Standards
- 8-(Trifluoromethoxy)chroman-4-one (CAS 276697-79-1)
- Ethyl 2-oxo-2-(3,4,5-trifluorophenyl)acetate (CAS 732251-58-0)
- 8-(bromomethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 2306265-77-8)
- Methyl 2-formyl-5-(trifluoromethyl)benzoate (CAS 2214294-00-3)
- 4',5'-Bis(4-aminophenyl)-[1,1':2',1''-terphenyl]-4,4''-diamine (CAS 2458125-05-6)
- 5-(Aminomethyl)furan-2-sulfonamide (CAS 712256-45-6)
- 3-(3-Chlorophenoxy)pyrrolidine hydrochloride (CAS 28491-00-1)
- Propranolol Impurity 17 (CAS 4199-10-4)
- 2-((4-Methoxyphenyl)ethynyl)benzaldehyde (CAS 176910-67-1)
- Methanone, [4-(3-azetidinyl)-1-piperazinyl]cyclopropyl- (CAS 930782-95-9)
- 2-(2-(4-Bromo-2,5-difluorophenoxy)ethyl)-1,3-dioxolane (CAS 1443345-36-5)
- 3-(Aminomethyl)isochroman (CAS 256229-12-6)
- 2-(4-Bromo-2-(difluoromethyl)-6-fluoropyridin-3-yl)acetonitrile (CAS 1804913-15-2)
- Neuropeptide SF (human) (CAS 192387-39-6)
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