Chlorhexidine Digluconate EP Impurity E CAS 45964-97-4
| CAS No. | 45964-97-4 |
| Molecular Formula | C7H8ClN3 |
| Molecular Weight | 169.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Chlorhexidine Digluconate EP Impurity E is closely related to a nitrile group, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Chlorhexidine Digluconate EP Impurity E (CAS 45964-97-4, C7H8ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Chlorhexidine Digluconate EP Impurity E (C7H8ClN3) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Chlorhexidine Digluconate EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8ClN3 |
| Molecular Weight | 169.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1970 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chlorhexidine Standards
- Chlorhexidine Impurity 20 (CAS 97904-31-9)
- Chlorhexidine Diacetate Impurity 4 (CAS 15894-70-9)
- Chlorhexidine Impurity 21 (CAS 2208-89-1)
- Chlorhexidine Impurity 22 (CAS CATO-C4X-225622)
- Chlorhexidine Impurity 23 (CAS CATO-C4X-225623)
- Chlorhexidine Impurity 31 (CAS CATO-C4X-225631)
- Chlorhexidine Impurity 25 (CAS CATO-C4X-225625)
- Chlorhexidine Impurity 32 (CAS CATO-C4X-225632)
Recommended Standards
- Clenbuterol impurity 11 (CAS 6953-83-9)
- N-Formyl-4-Chloro-2-Toluidine (CAS 21787-81-5)
- Acetaminophen Impurity 31 (CAS 587-65-5)
- N-Methyl-N-phenylcarbamoyl chloride (CAS 4285-42-1)
- Calcipotriol Impurity 45 (CAS CATO-C4X-122245)
- Metformin EP Impurity B Dinitrate (CAS 27369-26-2)
- Tacrolimus Impurity 28 (CAS 133941-75-0)
- Propyl 3-propoxypicolinate (CAS 134319-22-5)
- tert-Butyl 2-(((6-chloro-2-(methylthio)pyrimidin-4-yl)amino)methyl)pyrrolidine-1-carboxylate (CAS 1261229-91-7)
- Methyl 5-(4-hydroxyphenyl)-3-methylisoxazole-4-carboxylate (CAS 2112393-11-8)
- (R)-2-Amino-2-(4-methoxyphenyl)propanoic acid hydrochloride (CAS 871842-90-9)
- 4-Phenoxypiperidine (CAS 3202-33-3)
- 4,5-Dibromo-2-(difluoromethoxy)phenol (CAS 1805473-43-1)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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