Riluzole USP Related Compound A CAS 461-82-5
| CAS No. | 461-82-5 |
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Riluzole USP Related Compound A (CAS 461-82-5, C7H6F3NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Riluzole USP Related Compound A is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 177.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Riluzole USP Related Compound A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6F3NO |
| Molecular Weight | 177.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Riluzole Standards
Recommended Standards
- 936841-72-4 3-Methoxy-4-(trifluoromethyl)pyridine DTXSID40649098 (CAS 936841-72-4)
- 5-Hydrazinyl-2-(trifluoromethyl)pyridine (CAS 1035173-53-5)
- 216766-13-1 5-Methoxy-2-trifluoromethyl-pyridine 5-methoxy-2-(trifluoromethyl)pyridine A4659 (CAS 216766-13-1)
- N-(2,2,2-trifluoroethyl)pyrimidin-2-amine (CAS 1036455-18-1)
- Palbociclib Impurity 188 (CAS CATO-C4X-1125188)
- Evocalcet impurity 52 (CAS 1666124-30-6)
- Rebamipide impurity 03 (CAS 681806-75-7)
- 2-(Piperidin-3-yloxy)benzonitrile (CAS 902836-51-5)
- N-Cyclopentyl-2-((4-methoxyphenyl)sulfonamido)thiazole-4-carboxamide (CAS 1021213-34-2)
- (r)-tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (CAS 863453-61-6)
- 5-Bromo-4-chloro-1-methyl-1H-pyrazole (CAS 1521372-90-6)
- Indocyanine Green Impurity 26 (CAS 40880-56-6)
- Bis(N,N,N'N'-tetramethyl-L-tartramideglycolato)diboron (CAS 480438-22-0)
- D-Ile17-Tirzepatide (CAS CATO-CPTD788917)
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