Naloxone CAS 465-65-6
| CAS No. | 465-65-6 |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Naloxone is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Naloxone (CAS 465-65-6) is a high-purity analytical reference standard with the molecular formula C19H21NO4 and a molecular weight of 327.37 g/mol.
Naloxone (C19H21NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Naloxone Standards
- Naloxone Hydrochloride EP Impurity D (CAS 26451-92-3)
- Naloxone-D5 (CAS 1261079-38-2)
- Naloxone Impurity 16 (CAS CATO-C4X-149316)
- Naloxone Impurity 23 (CAS CATO-C4X-149323)
- Naloxone Impurity 18 (CAS CATO-C4X-149318)
- Naloxone EP Impurity G (CAS 70866-64-7)
- Naloxone Hydrochloride EP Impurity C (CAS 2139253-68-0)
- Naloxone Hydrochloride EP Impurity F (CAS 2139253-69-1)
Recommended Standards
- Laurotetanine impurity 1 (CAS 128-76-7)
- L-Stepholidine (CAS 16562-13-3)
- Papaverine Impurity 38 (CAS 726117-59-5)
- Sinoacutine (CAS 4090-18-0)
- 3-Cyclopropyl-3-azabicyclo[3.2.1]Octan-8-amine (CAS 1171939-07-3)
- 4-(5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazine-1-carbaldehyde (CAS 370071-21-9)
- N-methoxy-N-methyl-3,5-bis(trifluoromethyl)benzamide (CAS 329942-69-0)
- 2-(3,4-Dimethyl-phenylamino)-N-(4-methoxy-phenyl)-propionamide (CAS 1008681-88-6)
- 4-Bromo-2-(difluoromethyl)-3-nitropyridine-5-methanol (CAS 1806999-99-4)
- Cefadroxil Impurity 38 (CAS CATO-C4X-122438)
- 2-chloro-5-(trifluoromethyl)pyridin-4-ol (CAS 1211541-22-8)
- 5-Benzyl-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl hydrosulfide (CAS 21477-50-9)
- 2-(Piperazin-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole (CAS 1310383-68-6)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
Why CATO?
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