tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate CAS 470482-40-7
| CAS No. | 470482-40-7 |
| Molecular Formula | C11H18F3NO3 |
| Molecular Weight | 269.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate (CAS 470482-40-7), a certified reference material (molecular formula C11H18F3NO3, MW 269.26 g/mol) for analytical method development and quality control.
The molecular framework of tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate (C11H18F3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures tert-Butyl (2S,4S)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H18F3NO3 |
| Molecular Weight | 269.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- tert-Butyl (2S,4R)-4-hydroxy-2-(trifluoromethyl)piperidine-1-carboxylate (CAS 2613300-14-2)
- Tert-butyl (3R,5R)-3-hydroxy-5-(trifluoromethyl)piperidine-1-carboxylate (CAS 2165480-63-5)
- tert-Butyl (2S,4R)-2-(hydroxymethyl)-4-(trifluoromethyl)pyrrolidine-1-carboxylate (CAS 470482-43-0)
- Tert-butyl (3S,5S)-3-hydroxy-5-(trifluoromethyl)piperidine-1-carboxylate (CAS 2165897-55-0)
- ethyl 5-chloroimidazo[1,2-c]thieno[3,2-e]pyrimidine-2-carboxylate (CAS 1251003-30-1)
- 4-(Difluoromethyl)-6-iodo-3-methylpyridin-2-ol (CAS 1805061-12-4)
- 2-(quinolin-2-yl)ethanimidamide hydrochloride (CAS 1355498-05-3)
- 5-Fluoropyridine-3-carboximidamide (CAS 1201803-09-9)
- (2,4-Dinitro-5-piperidin-1-ylphenyl)amine acetate (CAS 1983937-99-0)
- n1,n1-Dimethyl-n2-(prop-2-yn-1-yl)ethane-1,2-diamine (CAS 1020972-51-3)
- (S)-3-(Benzyloxy)-10-hydroxy-2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinoline-6,14(5H,6aH)-dione (CAS 1971075-93-0)
- 4-(Boc-aminomethyl)benzyl Bromide (CAS 187283-17-6)
- 4-((2-Aminoethyl)amino)butan-1-ol (CAS 137020-06-5)
- Insulin Pork(≥27 USP units/mg) (CAS 12584-58-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com