Isotretinoin CAS 4759-48-2
| CAS No. | 4759-48-2 |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 300.44 g/mol gives Isotretinoin distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Isotretinoin (CAS 4759-48-2) is a high-purity analytical reference standard with the molecular formula C20H28O2 and a molecular weight of 300.44 g/mol.
The molecular framework of Isotretinoin (C20H28O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Isotretinoin Standards
- Isotretinoin EP Impurity F (CAS 68070-35-9)
- Isotretinoin EP Impurity D (CAS 5300-03-8)
- Isotretinoin-d5 (CAS CATO-C4X-196936)
- Isotretinoin EP Impurity H (CAS 71748-58-8)
- Isotretinoin EP Impurity G (5,6-Epoxy-13-cis Retinoic Acid) (and enantiomer) (CAS 81444-57-7)
- Isotretinoin EP Impurity I (CAS 75281-25-3)
- Isotretinoin Impurity 11 (CAS 14398-42-6)
- Isotretinoin Glucuronide (CAS 78147-42-9)
Recommended Standards
- Methandrostenolone (CAS 72-63-9)
- Ethynodiol (CAS 1231-93-2)
- Epristeride Impurity 4 (CAS CATO-C4X-30084)
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Why CATO?
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