Isotretinoin EP Impurity I CAS 75281-25-3
| CAS No. | 75281-25-3 |
| Molecular Formula | C20H28O3 |
| Molecular Weight | 316.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 316.43 g/mol gives Isotretinoin EP Impurity I distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Isotretinoin EP Impurity I (CAS 75281-25-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H28O3 and a molecular weight of 316.43 g/mol.
The molecular framework of Isotretinoin EP Impurity I (C20H28O3) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Isotretinoin EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H28O3 |
| Molecular Weight | 316.43 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
Related Isotretinoin Standards
- Isotretinoin EP Impurity G (5,6-Epoxy-13-cis Retinoic Acid) (and enantiomer) (CAS 81444-57-7)
- Isotretinoin EP Impurity H (CAS 71748-58-8)
- Isotretinoin-d5 (CAS CATO-C4X-196936)
- Isotretinoin EP Impurity F (CAS 68070-35-9)
- Isotretinoin EP Impurity D (CAS 5300-03-8)
- Isotretinoin (CAS 4759-48-2)
- Isotretinoin Impurity 11 (CAS 14398-42-6)
- Isotretinoin Glucuronide (CAS 78147-42-9)
Recommended Standards
- 5,8-Epoxy-13-cis Retinoic Acid (Mixture of Diastereomers) (CAS 112018-12-9)
- 4-Hydroxy-all-trans-Retinoic Acid (CAS 66592-72-1)
- 5,8-Epoxy-all-trans-Retinoic Acid(Mixture of Diastereomers) (CAS 3012-76-8)
- Lovastatin Impurity 39 (CAS CATO-C4X-168439)
- Flucloxacillin EP Impurity E (CAS CATO-C4X-16475)
- Glycopyrrolate Impurity 19 (CAS CATO-C4X-143119)
- Rivaroxaban Impurity 90 (CAS 59614-95-8)
- 1-Hydroxy-2-methyl-1H-1,3-benzodiazol-3-ium-3-olate (CAS 15966-52-6)
- 1-[2-(Methylsulfonyl)-4-nitrophenyl]pyrrolidine-2-carboxylic acid (CAS 1452572-57-4)
- tert-Butyl 5-fluoro-4-iodoisoindoline-2-carboxylate (CAS 2134649-47-9)
- Pantoprazole Impurity 56 (CAS 172282-50-7 (free bass))
- tert-Butyl 2-(cyclopentylsulfonyl)acetate (CAS 1504589-15-4)
- 4-(Cyclohexanecarboxamido)benzoic acid (CAS 180991-56-4)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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