1-(2,4-Dimethoxyphenyl)-1h-imidazole-2-thiol CAS 475997-84-3
| CAS No. | 475997-84-3 |
| Molecular Formula | C11H12N2O2S |
| Molecular Weight | 236.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(2,4-Dimethoxyphenyl)-1h-imidazole-2-thiol (CAS 475997-84-3) is a high-purity analytical reference standard with the molecular formula C11H12N2O2S and a molecular weight of 236.29 g/mol.
The molecular framework of 1-(2,4-Dimethoxyphenyl)-1h-imidazole-2-thiol (C11H12N2O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 1-(2,4-Dimethoxyphenyl)-1h-imidazole-2-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12N2O2S |
| Molecular Weight | 236.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Dimethoxyphenyl Standards
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- 5-(2,5-Dimethoxyphenyl)thiazol-2-amine (CAS 881040-41-1)
- 1-(2,5-dimethoxyphenyl)-1,3-diazinan-2-one (CAS 1140241-93-5)
- (R)-3-(2,5-Dimethoxyphenyl)piperazin-2-one (CAS 1228556-70-4)
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- (R)-3-(2,3-Dimethoxyphenyl)piperazin-2-one (CAS 1228565-90-9)
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Recommended Standards
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- 1-((2,5-Dimethylphenyl)sulfonyl)-1H-pyrazole (CAS 899233-12-6)
- 1-(4-Cyanophenyl)-N-cyclopropylmethanesulfonamide (CAS 949376-83-4)
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- 2-Amino-6-methyl-3-pyridinecarbothioamide (CAS 1249741-05-6)
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