9-Monodemethyl Minocycline CAS 4769-39-5
| CAS No. | 4769-39-5 |
| Molecular Formula | C22H25N3O7 |
| Molecular Weight | 443.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
9-Monodemethyl Minocycline (CAS 4769-39-5) is a certified pharmaceutical impurity reference standard with the molecular formula C22H25N3O7 and a molecular weight of 443.45 g/mol.
Based on its molecular formula C22H25N3O7, 9-Monodemethyl Minocycline contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 443.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25N3O7 |
| Molecular Weight | 443.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
Related Monodemethyl Standards
Recommended Standards
- Minocycline EP Impurity C (CAS 4708-96-7)
- Doxycycline Impurity 21 (CAS CATO-C4X-193121)
- Entacapone Impurity 35 (CAS CATO-C4X-162935)
- Doxycycline EP Impurity F (CAS 122861-53-4)
- Ambroxol Impurity 48 (CAS 2646700-91-4)
- Lomerizine Impurity 1 (CAS 1516207-30-9)
- Vonoprazan Impurity 257 (CAS CATO-C4X-1020257)
- 2-(1-Methyl-1H-indol-7-yl)acetonitrile (CAS 84548-95-8)
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