Doxycycline EP Impurity F CAS 122861-53-4
| CAS No. | 122861-53-4 |
| Molecular Formula | C23H25NO8 |
| Molecular Weight | 443.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Doxycycline EP Impurity F (CAS 122861-53-4, C23H25NO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H25NO8, Doxycycline EP Impurity F contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 443.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25NO8 |
| Molecular Weight | 443.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 1 |
Related Doxycycline Standards
- Doxycycline Impurity 21 (CAS CATO-C4X-193121)
- Doxycycline EP Impurity A (CAS 3219-99-6)
- Doxycycline EP Impurity C (CAS 6543-77-7)
- Doxycycline EP Impurity D (CAS 97583-08-9)
- Doxycycline Impurity 8 (CAS CATO-C4X-19318)
- Doxycycline (CAS 564-25-0)
- Doxycycline EP Impurity B (CAS CATO-C4X-19312)
- Doxycycline-d3 (CAS 2747918-45-0)
Recommended Standards
- Tetracycline EP Impurity B (CAS 6542-44-5)
- 9-Monodemethyl Minocycline (CAS 4769-39-5)
- T 3364366 (CAS 1356354-09-0)
- Minocycline EP Impurity C (CAS 4708-96-7)
- Lercanidipine Impurity 63 (CAS CATO-C4X-136463)
- Oseltamivir Impurity 39 (CAS CATO-C4X-172039)
- Doxapram Impurity 17 (CAS CATO-C4X-197317)
- 3-Acetyl-5-(4-Fluorobenzylidene)-4-Hydroxy-2(5H)-Thiophenone (CAS 5518-90-1)
- (4-Chlorophenyl)(2-methoxyphenyl)methanamine (CAS 1016696-64-2)
- 3-(3-Bromophenyl)-1-ethylpyrrolidine (CAS 1263280-03-0)
- Mivacurium Chloride Impurity 34 (CAS CATO-C4X-137534)
- rel-Diethyl (2R,3R)-oxirane-2,3-dicarboxylate (CAS 66647-17-4)
- ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 14757-98-3)
- Semaglutide impurity 100 (CAS CATO-C4X-2226100)
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