2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-ethoxyphenyl)ethanone CAS 477329-49-0
| CAS No. | 477329-49-0 |
| Molecular Formula | C25H22ClN3O2S |
| Molecular Weight | 463.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-ethoxyphenyl)ethanone.
2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-ethoxyphenyl)ethanone (CAS 477329-49-0) is a high-purity analytical reference standard with the molecular formula C25H22ClN3O2S and a molecular weight of 463.98 g/mol.
The molecular framework of 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-ethoxyphenyl)ethanone (C25H22ClN3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-ethoxyphenyl)ethanone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H22ClN3O2S |
| Molecular Weight | 463.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
- N-(2-Chloro-4,6-dimethylphenyl)-2-((5-(pyridin-4-yl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477318-73-3)
- 2-((4-Benzyl-5-((p-tolyloxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-chlorophenyl)ethan-1-one (CAS 443744-66-9)
- Ticagrelor Impurity 187 (CAS CATO-C4X-1093187)
- Mebeverine EP Impurity N (CAS CATO-C4X-16876)
- 2-Methyl-3-(methylthio)furan (CAS 63012-97-5)
- 2-Amino-6-(3,4-dimethoxyphenyl)-4-phenylpyridine-3-carbonitrile (CAS 156044-27-8)
- (S)-1-Cyclopropylethane-1,2-diamine hydrochloride (CAS 1810074-66-8)
- 2-(Bromomethyl)pyridin-3-ol hydrochloride (CAS 1001096-21-4)
- 1-((3-Chloropyridin-4-yl)methyl)-1h-1,2,3-triazol-4-amine (CAS 1518091-60-5)
- (6-Amino-5-methylpyridin-3-yl)boronic acid hydrochloride (CAS 2304635-84-3)
- 5-(Methylthio)pent-1-en-3-ol (CAS 1233883-43-6)
- 1-(2,6-Dimethylmorpholino)-3-methylbut-2-en-1-one (CAS 95594-79-9)
- 2-(5-amino-1,3,4-thiadiazol-2-yl)-N-phenylacetamide (CAS 310420-47-4)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
Why CATO?
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