4-(3-Chloro-4-fluorophenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione CAS 477334-48-8
| CAS No. | 477334-48-8 |
| Molecular Formula | C12H7ClFN3S2 |
| Molecular Weight | 311.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(3-Chloro-4-fluorophenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione.
4-(3-Chloro-4-fluorophenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 477334-48-8) is a high-purity analytical reference standard with the molecular formula C12H7ClFN3S2 and a molecular weight of 311.79 g/mol.
The molecular framework of 4-(3-Chloro-4-fluorophenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (C12H7ClFN3S2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(3-Chloro-4-fluorophenyl)-5-(thiophen-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7ClFN3S2 |
| Molecular Weight | 311.79 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Chloro Standards
- 8-Chloro-5-(piperazin-1-ylsulfonyl)isoquinoline (CAS 110408-12-3)
- 2-Chloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine (CAS 1197956-18-5)
- 5-Chloro-N-methyl-4-(methylamino)-N-phenylpyridine-3-sulfonamide (CAS 1352515-45-7)
- (E)-4-((6-chloro-4-oxothiochroman-3-ylidene)methyl)benzonitrile (CAS 900019-23-0)
- 2-Chloro-N-(2-methyl-4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetamide (CAS 304686-23-5)
- 4-Chloro-N-(4-formylpiperazine-1-carbonothioyl)benzamide (CAS 497060-71-6)
- 6-Chloro-N-(2,3-dimethylphenyl)-2-(methylsulfonyl)pyrimidin-4-amine (CAS 86627-00-1)
- Ethyl 2-[(3-chloro-2,2-dimethylpropanoyl)amino]-3-phenylpropanoate (CAS 1396999-17-9)
Recommended Standards
- 3-(5-Amino-4-(4-chlorophenyl)-1H-pyrazol-1-yl)tetrahydrothiophene 1,1-dioxide (CAS 321574-17-8)
- 4-[(4-Chlorophenyl)sulfanyl]-5H-pyrimido[5,4-b]indole (CAS 320420-19-7)
- 3-(4-Chlorophenyl)-7-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 439095-36-0)
- 2-{[5-(4-chlorophenyl)-4-ethyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 537017-32-6)
- 2-Chloro-3-(5-chloro-2-methoxyphenyl)-1-propene (CAS 951895-02-6)
- 2-(3-((((Benzyloxy)carbonyl)(isopropyl)amino)methyl)pyrrolidin-1-yl)acetic acid (CAS 1353947-29-1)
- 2-[2-(propan-2-yl)phenoxy]benzoic acid (CAS 1036554-70-7)
- 2,5-Pyridine dicarboxaldehyde (CAS 6221-01-8)
- N-(4-Bromophenyl)-N-(methylsulfonyl)glycine (CAS 425423-24-1)
- 4-(2,4-Dioxo-3-azabicyclo[3.1.0]hexan-3-yl)-2-(methylamino)butanoic acid (CAS 1340154-31-5)
- Phenylephrine Impurity 102 (CAS 1312706-19-6)
- Lumateperone Impurity 84 (CAS CATO-C4X-220184)
- 3-Borono-2,6-difluorobenzoic acid (CAS 1451393-05-7)
- Liraglutide (14-31)TFA Salt (CAS CATO-C4X-19927)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com