1-(4-Fluorophenyl)-3-((4-fluorophenyl)sulfonyl)propan-1-one CAS 477334-49-9
| CAS No. | 477334-49-9 |
| Molecular Formula | C15H12F2O3S |
| Molecular Weight | 310.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(4-Fluorophenyl)-3-((4-fluorophenyl)sulfonyl)propan-1-one (C15H12F2O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 1-(4-Fluorophenyl)-3-((4-fluorophenyl)sulfonyl)propan-1-one (CAS 477334-49-9), a certified reference material (molecular formula C15H12F2O3S, MW 310.32 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12F2O3S |
| Molecular Weight | 310.32 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluorophenyl Standards
- 2-(4-Fluorophenyl)-N-((5-phenylisoxazol-3-yl)methyl)acetamide (CAS 946340-21-2)
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Recommended Standards
- (E)-3-(dimethylamino)-1-(3-(3-fluorophenyl)benzo[c]isoxazol-5-yl)prop-2-en-1-one (CAS 383147-84-0)
- (2E)-3-(Dimethylamino)-1-[3-(4-fluorophenyl)-2,1-benzoxazol-5-yl]prop-2-en-1-one (CAS 321433-31-2)
- 3-(4-Fluorobenzyl)-4-hydroxy-1-(3-pyridinylmethyl)-2(1H)-pyridinone (CAS 477846-00-7)
- (1-(2-(Trifluoromethyl)-1,6-naphthyridin-5-yl)piperidin-4-yl)methanamine (CAS 909644-98-0)
- 1-(2,4-Dimethylphenyl)propan-1-one (CAS 35031-55-1)
- 4,5,7,8,12,13,15,16-Octafluoro[2.2]paracyclophane (CAS 1785-64-4)
- Tert-butyl 3-((methylthio)methyl)azetidine-1-carboxylate (CAS 1016233-16-1)
- 4,6-Dimethyl-3-(4-methylbenzenesulfonyl)-2-[(4-methylphenyl)sulfanyl]pyridine (CAS 478245-43-1)
- 2K-539S 338774-50-8 6-amino-2-hydroxy-5-[3-(trifluoromethyl)benzenesulfonyl]pyridine-3-carbonitrile (CAS 338774-50-8)
- 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}quinoxaline (CAS 339104-78-8)
- 2-(2-(Quinolin-8-yl)ethyl)cyclopentanone (CAS 920492-01-9)
- Butanedioic Acid 1-Methyl Ester (CAS 878205-29-9)
- 2-(Trifluoromethyl)benzene-1,4-diamine (CAS 364-13-6)
- Liraglutide Impurity 15 TFA Salt (CAS CATO-C4X-199215)
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